Results 341 to 350 of about 3,438,161 (393)
Some of the next articles are maybe not open access.
The structural basis of ribosome activity in peptide bond synthesis.
Science, 2000Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all-RNA active site.
P. Nissen +4 more
semanticscholar +1 more source
Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics
Bioorganic & Medicinal Chemistry, 2018The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher ...
Miloš Erak +3 more
openaire +3 more sources
The Current State of Peptide Drug Discovery: Back to the Future?
Journal of Medicinal Chemistry, 2017Over the past decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs and how this ...
Antoine Henninot, J. C. Collins, J. Nuss
semanticscholar +1 more source
Nonribosomal Peptide Synthesis-Principles and Prospects.
Angewandte Chemie, 2017Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more than 20 marketed drugs, such as antibacterials (penicillin, vancomycin),
R. Süssmuth, A. Mainz
semanticscholar +1 more source
Journal of Peptide Science, 1998
Siderophores are low molecular weight iron chelators, produced by virtually all bacteria, fungi and some plants. They serve to deliver the essential element iron, barely soluble under aerobic conditions, into microbial cells. Siderophores are therefore important secondary metabolites which are very often based on amino acids and their derivatives ...
G. Jung, H. Drechsel
openaire +3 more sources
Siderophores are low molecular weight iron chelators, produced by virtually all bacteria, fungi and some plants. They serve to deliver the essential element iron, barely soluble under aerobic conditions, into microbial cells. Siderophores are therefore important secondary metabolites which are very often based on amino acids and their derivatives ...
G. Jung, H. Drechsel
openaire +3 more sources
Archives of Physiology and Biochemistry, 2002
Corticotrophs were long thought to be a static, homogeneous population of cells that respond positively to hypothalamic stimulation, are inhibited by glucocorticoid feedback and secrete a single biologically active peptide, ACTH(1-39). Our current understanding is that this is an oversimplification and corticotrophs are a dynamic and more complex group
Schwartz, J. +5 more
openaire +4 more sources
Corticotrophs were long thought to be a static, homogeneous population of cells that respond positively to hypothalamic stimulation, are inhibited by glucocorticoid feedback and secrete a single biologically active peptide, ACTH(1-39). Our current understanding is that this is an oversimplification and corticotrophs are a dynamic and more complex group
Schwartz, J. +5 more
openaire +4 more sources
Life Sciences, 1973
Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
openaire +3 more sources
Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
openaire +3 more sources
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.
Biochemical and Biophysical Research Communications - BBRC, 1993A novel hypotensive peptide was discovered in human pheochromocytoma by monitoring the elevating activity of platelet cAMP. Since this peptide is abundant in normal adrenal medulla as well as in pheochromocytoma tissue arising from adrenal medulla, it ...
K. Kitamura +6 more
semanticscholar +1 more source
Selection and application of peptide-binding peptides
Nature Biotechnology, 2000Peptide-binding ligands would be useful for directing reagents to particular epitopes in a protein, the detection of peptide hormones, and many other applications. Here we show that peptides of modest size isolated from a library using a simple genetic assay can act as specific receptors for other peptides.
Weiguang Zhu +2 more
openaire +3 more sources
Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.
International journal of peptide & protein research, 20099-Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide synthesis methodology has been greatly enhanced by the introduction of a variety of
G. Fields, R. Noble
semanticscholar +1 more source