Results 121 to 130 of about 82,531 (244)

Association between dry eye and myopia in schoolchildren: current evidence and possible mechanisms. [PDF]

Front Med (Lausanne)
Wang H, Zhang HY.
europepmc   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Observing intersubunit dynamics in single yeast ribosomes. [PDF]

Nucleic Acids Res
Das A, Grove AK, Ivanov AV, Wakabayashi H, Ermolenko DN.   +4 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Classical Phytohormones and Peptide Plant Hormones in Abiotic Stress Tolerance: Crosstalk, Physiological Integration, and Crop Improvement. [PDF]

Plants (Basel)
Ali B, Imran A, Iftikhar H, Khan Z, Saeed F, Hussain Z, Waheed A, Abdel Latef AAH, Imin N.   +8 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Crystals of a large tryptic peptide (fragment A) of elongation factor EF‐Tu from Escherichia coli

FEBS Letters, 1977
Gast, W., Kabsch, W., Wittinghofer, A., Lebermann , R.   +3 more
openaire   +4 more sources

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Piezo‐Coupling Effects in Smart Polymers: Toward Ultrasensitive Sensing and Biomedical Applications

Advanced Science, EarlyView.
Piezo‐coupling effects are the foundational factors for the development of multifunctional and self‐powered platforms. Central to this advancement is the use of stimuli‐responsive smart polymers, which offer mechanical flexibility, biocompatibility, and simplified structural complexity with improved sensitivity and energy efficiency.
Duc Khanh Tran, Tuan Sang Tran, Thanh‐An Truong, Trung‐Hieu Vu, That Buu Ton, Dzung Viet Dao, Van Thanh Dau   +6 more
wiley   +1 more source