Results 1 to 10 of about 226,375 (115)

Risk factors for carfilzomib-related cardiovascular adverse events in Chinese patients with multiple myeloma: A real-world retrospective cohort study [PDF]

Journal of International Medical Research
Background Although an association between carfilzomib and cardiovascular adverse events has been well documented, the risk factors for carfilzomib-induced cardiovascular adverse events in the Chinese population remain unclear.
Xiao-Chen Wei, Fan Chen, Ying Xiao, Hai-Rong Lyu   +3 more
doaj   +2 more sources

Real-time search-assisted multiplexed quantitative proteomics reveals system-wide cryptic translation initiation in human cancer cells [PDF]

Genome Biology
Background It is generally considered that eukaryotic translation initiation prominently occurs from the first AUG codon by ribosomal scanning from the 5-cap end of each mRNA.
Hiroko Kozuka-Hata, Tomoko Hiroki, Aya Kitamura, Naoaki Miyamura, Tetsu Akiyama, Jun-ichiro Inoue, Kouhei Tsumoto, Masaaki Oyama   +7 more
doaj   +2 more sources

A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1

Microbiology Spectrum
A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial ...
Elvira Alanis, Faith Aguilar, Niaz Banaei, Frank B. Dean, Alexa Villarreal, Miguel Alanis, Karen Lozano, James M. Bullard, Yonghong Zhang   +8 more
doaj   +3 more sources

Associations between oral migraine preventive regimens and CGRP monoclonal antibody initiation: real-world evidence from a resource-limited setting [PDF]

BMC Neurology
Background Calcitonin gene–related peptide monoclonal antibodies (CGRP mAbs) are effective migraine-specific preventive therapies; however, access remains limited in many low- and middle-income countries (LMICs).
Sekh Thanprasertsuk, Akarin Hiransuthikul, Sirawit Roongrojwittayakul, Thanakit Pongpitakmetha, Wanakorn Rattanawong, Prakit Anukoolwittaya   +5 more
doaj   +2 more sources

Elucidation of the Translation Initiation Factor Interaction Network of Haloferax volcanii Reveals Coupling of Transcription and Translation in Haloarchaea

Frontiers in Microbiology, 2021
Translation is an important step in gene expression. Initiation of translation is rate-limiting, and it is phylogenetically more diverse than elongation or termination. Bacteria contain only three initiation factors. In stark contrast, eukaryotes contain
Franziska Schramm, Andreas Borst, Uwe Linne, Jörg Soppa   +3 more
doaj   +1 more source

Disparities in SGLT2 Inhibitor or Glucagon-Like Peptide 1 Receptor Agonist Initiation Among Medicare-Insured Adults With CKD in the United StatesPlain-Language Summary

Kidney Medicine, 2023
Rationale & Objective: Information regarding disparities in initiating sodium/glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) in patients with chronic kidney disease (CKD) is limited.
Julie Z. Zhao, Eric D. Weinhandl, Angeline M. Carlson, Wendy L. St. Peter   +3 more
doaj   +1 more source

Dual Toxic-Peptide-Coding Staphylococcus aureus RNA under Antisense Regulation Targets Host Cells and Bacterial Rivals Unequally

Cell Reports, 2014
Summary: Produced from the pathogenicity islands of Staphylococcus aureus clinical isolates, stable SprG1 RNA encodes two peptides from a single internal reading frame. These two peptides accumulate at the membrane, and inducing their expression triggers
Marie-Laure Pinel-Marie, Régine Brielle, Brice Felden   +2 more
doaj   +1 more source

Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Cancer Cell International, 2020
The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins.
Gao-Qi Wu, Yan-Ming Xu, Andy T. Y. Lau
doaj   +1 more source

The regulation of TCR signalling by the spatial organisation of membrane proteins

Frontiers in Immunology, 2012
T cell signalling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor’s ITAM domains by the kinase Lck.
Jeremie eRossy, David J. Williamson, Katharina eGaus   +2 more
doaj   +1 more source

Transcriptome profiling of laser-captured crown root primordia reveals new pathways activated during early stages of crown root formation in rice.

PLoS ONE, 2020
Crown roots constitute the main part of the rice root system. Several key genes involved in crown root initiation and development have been identified by functional genomics approaches. Nevertheless, these approaches are impaired by functional redundancy
Jérémy Lavarenne, Mathieu Gonin, Antony Champion, Marie Javelle, Hélène Adam, Jacques Rouster, Geneviève Conejéro, Marc Lartaud, Jean-Luc Verdeil, Laurent Laplaze, Christophe Sallaud, Mikael Lucas, Pascal Gantet   +12 more
doaj   +1 more source