Results 61 to 70 of about 8,430,864 (251)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system

Virulence, 2018
Streptococcus gallolyticus subsp. gallolyticus, formerly classified as S. bovis biotype I, is an increasing cause of bacteremia and infective endocarditis in the elderly.
Julia Isenring, Juliane Köhler, Masanobu Nakata, Marcus Frank, Christoph Jans, Pierre Renault, Camille Danne, Shaynoor Dramsi, Bernd Kreikemeyer, Sonja Oehmcke-Hecht   +9 more
doaj   +1 more source

How Mistimed and Unwanted Pregnancies Affect Timing of Antenatal Care Initiation in three Districts in Tanzania [PDF]

, 2013
Early antenatal care (ANC) initiation is a doorway to early detection and management of potential complications associated with pregnancy. Although the literature reports various factors associated with ANC initiation such as parity and age, pregnancy ...
Hingora, Ahmed, Senga Pemba, Exavery, Amon, Godfrey Mbaruku, Kanté, Almamy Malick, Exavery Amon, Pemba Senga, Amon Exavery, Mbaruku Godfrey, Phillips, James F., Mbaruku, Godfrey, Phillips James F, Phillips, James F, James F Phillips, Pemba, Senga, Kanté Almamy Malick, Hingora Ahmed, Almamy Malick Kanté, Ahmed Hingora   +18 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The effects of dietary fibre type on satiety-related hormones and voluntary food intake in dogs [PDF]

, 2009
Depending on type and inclusion level, dietary fibre may increase and maintain satiety and postpone the onset of hunger. This 7-week study evaluated the effect of fibre fermentability on physiological satiety-related metabolites and voluntary food intake
Bosch, G., Hesta, M., Janssens, G.P.J., Poel, A.F.B., van der, Verbrugghe, A., Hendriks, W.H., Holst, J.J.   +6 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice

Biochemistry and Biophysics Reports
Aim: Liver cirrhosis is a serious disease characterized by liver dysfunction and severe fibrosis; however, no breakthrough drugs have effectively improved fibrosis, making it an unmet medical need.
Masaki Mito, Atsunori Tsuchiya, Soichi Ishii, Takafumi Tonouchi, Kaito Furuyama, Ryo Jinbo, Nobutaka Takeda, Hiroyuki Abe, Katsuto Tamai, Shuji Terai   +9 more
doaj   +1 more source

Factors promoting initiation of cigarette smoking among adolescents in rural and urban areas in Oyo state, Nigeria

, 2018
Background Nigeria is a signatory to the WHO Framework Convention on Tobacco Control (FCTC) and the Tobacco Control Bill was signed in 2015. In spite of these, there are indications that many adolescents still smoke cigarettes.
Olayemi Omotade, Adesola Olumide, Amir Shmueli   +2 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source