Results 71 to 80 of about 8,430,864 (251)
Peptide antibody tools to dissect specific functions of eIF4A paralogs in cancer
Discover OncologyEukaryotic translation initiation factors (eIFs) are key regulators of messenger RNA (mRNA) translation, a process highly dysregulated in cancer. Among these paralogs, eIF4A1 and eIF4A2 are closely related DEAD box mRNA helicases that, despite their high
Shobhit Srivastava +3 more
doaj +1 more source
Risk factors for trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients
Frontiers in OncologyObjectiveTo analyze the risk factors for cardiotoxicity induced by trastuzumab in human epidermal growth factor receptor 2 (HER2) -positive breast cancer patients and provide a basis for early clinical intervention.MethodsA retrospective analysis was ...
Hao Zhang, Shenbao Hu, Niya Kong
doaj +1 more source
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification [PDF]
, 2008 *Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own disadvantages such as the immense volume of tandem Mass ...
Zengyou He +5 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
BiologyN, as plants’ most essential nutrient, profoundly shapes root system architecture (RSA), with LRs being preferentially regulated. This review synthesizes the intricate molecular mechanisms underpinning N sensing, signaling, and its integration into ...
Xichao Sun +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Cardiovascular DiabetologyObjective To evaluate the efficacy of anti-CD3 monoclonal antibody (mAb) in patients with type 1 diabetes (T1D) and identify the influencing factors.
Qi Wu +5 more
doaj +1 more source
Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]
, 2013 Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Kazana, Eleanna +5 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
PLoS ONEBackgroundPrior studies have shown disparities in the uptake of cardioprotective newer glucose-lowering drugs (GLDs), including sodium-glucose cotranwsporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1a). This study aimed to
Wei-Han Chen +11 more
doaj +1 more source