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Antisense Properties of Peptide Nucleic Acid
1998The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
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Automated Synthesis of Peptide Nucleic Acids and Peptide Nucleic Acid–Peptide Conjugates
Analytical Biochemistry, 1999L D, Mayfield, D R, Corey
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Peptide Nucleic Acids (PNA) [PDF]
, 2002 A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole +3 more
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2006
PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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2004
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole +3 more
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A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole +3 more
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MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2014Ioana Berindan-Neagoe +2 more
exaly
Antisense peptide nucleic acids.
Current opinion in molecular therapeutics, 2001Within the past couple of years peptide nucleic acid (PNA) antisense and antigene technology has entered the realm of biological and preclinical studies. This is primarily due to the development of a number of novel methods for more efficient delivery of PNA oligomers to eukaryotic cells.
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