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Antisense Properties of Peptide Nucleic Acid
1998The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
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ChemInform Abstract: Peptide Nucleic Acids: Analogues and Derivatives
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ganesh, Krishna N., Nielsen, Peter Eigil
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Nucleic Acid Independent Synthesis of Peptides
1981In this review we summarize some results on enzymatic peptide biosynthesis, the subject has been reviewed recently (Kurahashi 1974; Froyshov et al. 1978; Katz and Demain 1977; Laland et al. 1978; Vining and Wright 1977; Kleinkauf and Koischwitz 1978). We will extent the concepts of enzymatic peptide elongation reactions which we have summarized earlier
Horst Kleinkauf, H von Döhren
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Peptide nucleic acids as therapeutic agents
Current Opinion in Structural Biology, 1999Peptide nucleic acids (PNAs) have been around for more than seven years and it was hoped, at their introduction, that they would quickly enter the fields of antisense and antigene technology and drug development. Despite their extremely favorable hybridization and stability properties, as well as the encouraging antisense and antigene activity of PNA ...
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Automated Synthesis of Peptide Nucleic Acids and Peptide Nucleic Acid–Peptide Conjugates
Analytical Biochemistry, 1999David R. Corey, Lynn D. Mayfield
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2006
PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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Nucleic Acids, Peptides, and Proteins
1975The roles played by the solvent and small solute-solvent interactions in aqueous solutions of proteins, polypeptides, and nucleic acids are in many aspects far from clear; the total effort which has so far been expended in advancing our knowledge of the phenomena has been quite considerable and yet many problems and anomalies remain to be explained. It
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Antisense peptide nucleic acids.
Current opinion in molecular therapeutics, 2001Within the past couple of years peptide nucleic acid (PNA) antisense and antigene technology has entered the realm of biological and preclinical studies. This is primarily due to the development of a number of novel methods for more efficient delivery of PNA oligomers to eukaryotic cells.
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Nature Biotechnology, 1998