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The Chemistry of Peptide Nucleic Acids
ChemInform, 2001AbstractFor Abstract see ChemInform Abstract in Full Text.
Ralph A. Casale, Michael Egholm
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ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Arif Ali, Shabih Shakeel, Sajjad Karim
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Arif Ali, Shabih Shakeel, Sajjad Karim
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Synthesis of Peptide Nucleic Acid–Peptide Conjugates
2004Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
David R. Corey, Kunihiro Kaihatsu
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Photocatalysis with nucleic acids and peptides
Physical Sciences Reviews, 2018Abstract In chemical photocatalysis, the photophysical process is coupled to a subsequent chemical reaction. The absorbed light energy contributes to the overall energy balance of the reaction and thereby increases its sustainability. Additionally, oligonucleotides and oligopeptides offer the possibility to control regio- and stereoselectivity as ...
Alexander Penner +4 more
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A Review of Peptide Nucleic Acid
Advanced Techniques in Biology & Medicine, 2015Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone. It is chemically stable and resistant to hydrolytic cleavage.
Kobun Rovina +2 more
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Peptide Nucleic Acids and the Origin of Life
Chemistry & Biodiversity, 2007AbstractThe possibilities of pseudo‐peptide‐DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the ...
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Peptide nucleic acids: Expanding the scope of nucleic acid recognition
Trends in Biotechnology, 1997Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible ...
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Nucleobase Modifications in Peptide Nucleic Acids
Current Topics in Medicinal Chemistry, 2007Peptide nucleic acid (PNA) is an oligonucleotide mimic originally designed upon a repeating N-(2-aminoethyl)glycine polyamide backbone to which nucleobase heterocycles are attached through a methylene carbonyl linkage to the alpha-amino group. These molecules possess remarkable hybridization properties with DNA or RNA forming complexes with high ...
Robert H. E. Hudson, Filip Wojciechowski
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2007
Peptide nucleic acids (PNAs) can be conveniently delivered into cells in complex with DNA and cationic lipid. This advance enables researchers to test the hypothesis that PNAs offer advantages for recognition of DNA or RNA targets within cells. In this review, I describe the intracellular delivery of PNAs as DNA-PNA-cationic lipid complexes and discuss
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Peptide nucleic acids (PNAs) can be conveniently delivered into cells in complex with DNA and cationic lipid. This advance enables researchers to test the hypothesis that PNAs offer advantages for recognition of DNA or RNA targets within cells. In this review, I describe the intracellular delivery of PNAs as DNA-PNA-cationic lipid complexes and discuss
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