Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics. [PDF]
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5-Triazolyl uracil improves nucleobase stacking, pyrimidine recognition, biological activity, and specificity of RNA-binding triplex-forming peptide nucleic acids. [PDF]
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Peptide nucleic acid (PNA) — a review
Journal of Chemical Technology and Biotechnology, 2006AbstractPeptide nucleic acid (PNA) is a nucleobase oligomer in which the entire backbone has been replaced by a backbone composed of N‐(2‐aminoethyl)glycine units. In other words, PNA can be regarded as DNA with a neutral peptide backbone instead of a negatively charged sugar–phosphate backbone.
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Peptide Nucleic Acids (PNAs), A Chemical Overview
Current Medicinal Chemistry, 2005Peptide nucleic acid (PNA) is a nucleic acid analogue and a fully synthetic DNA/RNA-recognising ligand with a neutral peptide-like backbone. In spite of the large change on the backbone structure, PNA molecules bind strongly to complementary DNA and RNA sequences. Originally conceived as ligand for the recognition of double stranded DNA, the unique
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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