Results 311 to 320 of about 677,914 (356)

Peptide-Templated Nucleic Acid Ligation [PDF]

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew Levy, Andrew D. Ellington
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Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids.

Current pharmaceutical design, 2019
BACKGROUND Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications ...
Shipra Malik, Brenda Asmara, Zoe M. Moscato, J. Mukker, R. Bahal   +4 more
semanticscholar   +1 more source

Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
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Olefinic Peptide Nucleic Acid (OPA)

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Christian J. Leumann, Daniel Gautschi
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Peptide Nucleic Acids for MicroRNA Targeting

2020
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R., Gasparello J., Fabbri E., Borgatti M., Tamanini A., Finotti A.   +5 more
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Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide.

ACS Nano, 2021
Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense oligonucleotide (ASO).
Lei Chen, Gaigai Li, Xingxing Wang, Jinbo Li, Yan Zhang   +4 more
semanticscholar   +1 more source

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ning Zhang, Ethan A. Englund, Daniel H. Appella   +2 more
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Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly.

Journal of the American Chemical Society, 2015
Nucleic acids are an attractive platform for organizing molecular self-assembly because of their specific nucleobase interactions and defined length scale.
Iulia A Sacui, Wei-Che Hsieh, Arun K. Manna, Bichismita Sahu, Danith H. Ly   +4 more
semanticscholar   +1 more source

Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Robert H. E. Hudson, Russell D. Viirre, N. McCourt, J. Tse   +3 more
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Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
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