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Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
Mary Rusckowski   +3 more
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Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
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The Chemistry of Peptide Nucleic Acids

ChemInform, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ralph A. Casale, Michael Egholm
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Peptide Nucleic Acids (PNAs)

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Arif Ali, Shabih Shakeel, Sajjad Karim
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Peptide modules for overcoming barriers of nucleic acids transport to cells.

Current Topics in Medicinal Chemistry, 2015
Absence of safe and efficient methods of nucleic acids delivery is one of the major issues which limits the development of human gene therapy. Highly efficient viral vectors raise questions due to safety reasons.
A. Egorova, A. Kiselev
semanticscholar   +1 more source

Synthesis of Peptide Nucleic Acid–Peptide Conjugates

2004
Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
David R. Corey, Kunihiro Kaihatsu
openaire   +2 more sources

Photocatalysis with nucleic acids and peptides

Physical Sciences Reviews, 2018
Abstract In chemical photocatalysis, the photophysical process is coupled to a subsequent chemical reaction. The absorbed light energy contributes to the overall energy balance of the reaction and thereby increases its sustainability. Additionally, oligonucleotides and oligopeptides offer the possibility to control regio- and stereoselectivity as ...
Alexander Penner   +4 more
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A Review of Peptide Nucleic Acid

Advanced Techniques in Biology & Medicine, 2015
Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone. It is chemically stable and resistant to hydrolytic cleavage.
Kobun Rovina   +2 more
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Peptide Nucleic Acids and the Origin of Life

Chemistry & Biodiversity, 2007
AbstractThe possibilities of pseudo‐peptide‐DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the ...
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Peptide nucleic acids: Expanding the scope of nucleic acid recognition

Trends in Biotechnology, 1997
Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible ...
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