Results 321 to 330 of about 690,671 (364)

Peptide-Templated Nucleic Acid Ligation [PDF]

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew Levy, Andrew D. Ellington
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Olefinic Peptide Nucleic Acid (OPA)

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Christian J. Leumann, Daniel Gautschi
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Peptide Nucleic Acids for MicroRNA Targeting

2020
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R., Gasparello J., Fabbri E., Borgatti M., Tamanini A., Finotti A.   +5 more
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Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide.

ACS Nano, 2021
Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense oligonucleotide (ASO).
Lei Chen, Gaigai Li, Xingxing Wang, Jinbo Li, Yan Zhang   +4 more
semanticscholar   +1 more source

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ning Zhang, Ethan A. Englund, Daniel H. Appella   +2 more
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Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Robert H. E. Hudson, Russell D. Viirre, N. McCourt, J. Tse   +3 more
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Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
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Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
Mary Rusckowski, F. Chang, Donald Hnatowich, T. Qu   +3 more
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Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
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The Chemistry of Peptide Nucleic Acids

ChemInform, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ralph A. Casale, Michael Egholm
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