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Inhibition of miRNA Maturation by Peptide Nucleic Acids [PDF]
, 2013 Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
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Antisense properties of peptide nucleic acid
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999Peptide nucleic acid (PNA) is a nucleic acid mimic in which the deoxyribose phosphate backbone has been replaced by a pseudo-peptide polymer to which the nucleobases are linked. PNA-oligomers can be synthesized in relatively large amounts, are highly stable in biological environments, and bind complementary DNA and RNA targets with remarkably high ...
Larsen, H J +2 more
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ELECTROPHORESIS, 2019
AbstractA rapid, high resolution, and low sample consumption CZE method is developed for peptide nucleic acid (PNA) analysis for the first time. 30% v/v acetonitrile in PNA sample and 20% v/v acetonitrile in 50 mM borax‐boric acid (pH 8.7) as BGE were employed after optimization.
Xiaoqian Wang +3 more
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AbstractA rapid, high resolution, and low sample consumption CZE method is developed for peptide nucleic acid (PNA) analysis for the first time. 30% v/v acetonitrile in PNA sample and 20% v/v acetonitrile in 50 mM borax‐boric acid (pH 8.7) as BGE were employed after optimization.
Xiaoqian Wang +3 more
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Antisense Properties of Peptide Nucleic Acid
1998The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
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ChemInform Abstract: Peptide Nucleic Acids: Analogues and Derivatives
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ganesh, Krishna N., Nielsen, Peter Eigil
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Nucleic Acid Independent Synthesis of Peptides
1981In this review we summarize some results on enzymatic peptide biosynthesis, the subject has been reviewed recently (Kurahashi 1974; Froyshov et al. 1978; Katz and Demain 1977; Laland et al. 1978; Vining and Wright 1977; Kleinkauf and Koischwitz 1978). We will extent the concepts of enzymatic peptide elongation reactions which we have summarized earlier
Horst Kleinkauf, H von Döhren
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Peptide nucleic acids as therapeutic agents
Current Opinion in Structural Biology, 1999Peptide nucleic acids (PNAs) have been around for more than seven years and it was hoped, at their introduction, that they would quickly enter the fields of antisense and antigene technology and drug development. Despite their extremely favorable hybridization and stability properties, as well as the encouraging antisense and antigene activity of PNA ...
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Automated Synthesis of Peptide Nucleic Acids and Peptide Nucleic Acid–Peptide Conjugates
Analytical Biochemistry, 1999David R. Corey, Lynn D. Mayfield
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2006
PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to
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