Results 71 to 80 of about 3,893,535 (160)

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Results and adverse events of personalized peptide receptor radionuclide therapy with 90Yttrium and 177Lutetium in 1048 patients with neuroendocrine neoplasms [PDF]

, 2018
Peptide receptor radionuclide therapy (PRRT) of patients with somatostatin receptor expressing neuroendocrine neoplasms has shown promising results in clinical trials and a recently published phase III study.In our center, 2294 patients were screened ...
Baum, Richard P., Hommann, Merten, Robiller, Franz C., Dieter Hörsch, Aviral Singh, Dirk Mueller, Lambin, Philippe, Richard P. Baum, Mueller, Dirk, Daniel Kaemmerer, Arthur Jochems, Jochems, Arthur, Holger Franz, Kaemmerer, Daniel, Karin Niepsch, Franz C. Robiller, Kulkarni, Harshad R., Philippe Lambin, Vikas Prasad, Prasad, Vikas, Holger, Franz, Merten Hommann, Harshad R. Kulkarni, Singh, Aviral, Horsch, Dieter, Niepsch, Karin   +25 more
core   +2 more sources

Lanreotide, a Somatostatin Analogue, in Advanced Merkel Cell Carcinoma: A Prospective Single‐Arm Phase II Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine and epithelial skin cancer. Somatostatin analogues, such as lanreotide, have shown efficacy in managing other neuroendocrine tumors. Retrospective studies suggest that lanreotide may induce partial response or disease stabilization in patients with advanced MCC.
Julie Charles, Aude Belbezier, Stéphane Mouret, Brigitte Dreno, Stéphane Dalle, Céleste Lebbe, Ewa Hainaut‐Wierzbicka, Andreea Stefan, Julie de Quatrebarbes, Olivier Dereure, Ouidad Zehou, Sandrine Mansard, Alain Dupuy, Caroline Dutriaux, Florent Grange, Caroline Gaudy‐Marqueste, Henri Montaudié, Jean‐Philippe Arnault, Yannick Le Corre, Thibault Kervarrec, Jean‐Louis Quesada, Mahtab Samimi, Marie‐Thérèse Leccia, The Group of Cutaneous Oncology of the French Society of Dermatology   +23 more
wiley   +1 more source

MULTIMODALITY RADIONUCLIDE DIAGNOSTIC IMAGING FOR PERSONALISED TARGETED RADIONUCLIDE THERAPY IN PHEOCHROMOCYTOMAS AND PARAGANGLIOMAS: CASE SERIES [PDF]

Egyptian Journal of Nuclear Medicine
Pheochromocytomas and paragangliomas, commonly referred to as PPGLs, are rare neuroendocrine tumours that occur in adolescents and children. It arises from the chromaffin tissue of the adrenal medulla and extra-adrenal sympathetic/parasympathetic ganglia.
Fairuz Nurliyana Mahalil, Khadijah Hamid, Mohd Wajdi Ghazali   +2 more
doaj   +1 more source

Gastric Emptying in Obesity and Weight‐Loss Interventions: Physiology, Assessment, and Clinical Implications

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Obesity is associated with accelerated gastric emptying. Weight‐loss interventions each impose a distinct emptying signature: acceleration after sleeve gastrectomy and gastric bypass, delay after endoscopic sleeve gastroplasty, intragastric balloon, and GLP‐1 receptor agonists.
Maxime Amoyel, Rachida Lebtahi, Tigran Poghosyan, Maude Le Gall, Heithem Soliman   +4 more
wiley   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Meeting Notes of the Taiwan Neuroendocrine Tumor Society & Taiwan Society of Nuclear Medicine Joint Conference - Peptide Receptor Radionuclide Therapy Targeting for Gastroenteropancreatic Neuroendocrine Tumors: Basic Principles and State-of-the-art Clinical Practice

Journal of Cancer Research and Practice
Objective: The current study aimed to investigate the basic principles and clinical applications, including the selection of proper candidates, follow-up strategies, and radiation protection issues relating to peptide receptor radionuclide therapy (PRRT).
Mei-Fang Cheng, Chih-Chieh Yen, Jeng-Shiun Du, Yu-Li Chiu, Ming-Huang Chen, Hui-Jen Tsai, I-Chen Wu, Hueng-Yuan Shen, Ruoh-Fang Yen, Li-Tzong Chen, On Behalf of Taiwan Neuroendocrine Tumor Society and Taiwan Society of Nuclear Medicine   +10 more
doaj   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Controversies in NEN: An ENETS position statement on the role of liver transplantation (LT) in patients with advanced small‐intestinal and pancreatic NETs

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Liver transplantation (LT) may offer survival or symptomatic benefit for highly selected patients with advanced, well‐differentiated small‐intestinal or pancreatic neuroendocrine tumours and unresectable liver‐dominant metastases. However, its role remains controversial, as LT is rarely curative, recurrence is common, and benefits must be ...
Peter Stålberg, Mairéad G. McNamara, Simona Grozinsky‐Glasberg, Andreas Pascher, Beata Kos‐Kudla, Timm Denecke, Nehara Begum, Wendy Martin, Stephanie Alband, Clarisse Dromain, Raj Srirajaskanthan, Eric Baudin   +11 more
wiley   +1 more source