Results 71 to 80 of about 939,420 (304)

A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer

Journal for ImmunoTherapy of Cancer, 2017
Background Breast cancer remains a leading cause of cancer death worldwide. There is evidence that immunotherapy may play a role in the eradication of residual disease. Peptide vaccines for immunotherapy are capable of durable immune memory, but vaccines
Patrick M. Dillon, Gina R. Petroni, Mark E. Smolkin, David R. Brenin, Kimberly A. Chianese-Bullock, Kelly T. Smith, Walter C. Olson, Ibrahim S. Fanous, Carmel J. Nail, Christiana M. Brenin, Emily H. Hall, Craig L. Slingluff   +11 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

CPP–PEG‐Guided Surface Engineering of Mitochondria Enables Efficient Cellular Uptake and Respiratory Modulation

Advanced Materials Interfaces, EarlyView.
PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi, Yukari Muramatsu, Akihiro Nakaya, Yuji Maruo, Rick C. Tsai, Masashi Suganuma, Hisashi Ohta, Atsuhito Takeda, Hideyoshi Harashima, Yuma Yamada   +9 more
wiley   +1 more source

A 5-year follow-up of antibody response in children vaccinated with single dose of live attenuated SA14-14-2 Japanese encephalitis vaccine: immunogenicity and anamnestic responses

, 2008
Out of 98 subjects who had participated in the 2000 JE vaccination campaign, 69 people were enrolled in the tests of 2004 and 2005 for the evaluation of long term immune response of a single dose of live attenuated SA14-14-2 JE vaccine.
오희철
core   +1 more source

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial [PDF]

, 2008
Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine.
Zurbriggen, R, Gerd Pluschke, Sarah C. Gilbert, Hill, Adrian, Hutchings, Claire, Gilbert Sarah C., Sinden, Robert, Gilbert, Sarah, Pluschke, G, Gilbert, Sarah C., Zurbriggen Rinaldo, Vogel, Denise, Jack L. Williams, Correa, S, Andrews Laura, Okitsu, SL, Westerfeld Nicole, Andrews, Laura, Vogel, D, David W. Porter, Thompson, Fiona, Okitsu, Shinji, Ian Poulton, Todryk, S, Shinji L. Okitsu, Denise Vogel, Dunachie Susanna, Thompson Fiona M., Berthoud, Tamara, Andrews, L, Sinden, R, Porter David W., Pluschke, Gerd, Sarah C Gilbert, Sinden Robert, Poulton Ian, Fiona M Thompson, Berthoud, T, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Susanna Dunachie, Westerfeld, Nicole, Tamara Berthoud, Todryk, Stephen, Okitsu Shinji L., Hill Adrian V. S., Correa Simon, Berthoud Tamara, Dunachie, S, Westerfeld, N, David W Porter, Nicole Westerfeld, Todryk Stephen, Porter, David, Correa, Simon, Thompson, FM, Pluschke Gerd, Hutchings, C, Poulton, Ian, Hutchings Claire, Williams, JL, Vogel Denise, Shinji L Okitsu, Fiona M. Thompson, Poulton, I, Jack L Williams, Simon Correa, Laura Andrews, Dunachie, Susanna, Adrian V S Hill, Robert Sinden, Porter, DW, Stephen Todryk, Williams, Jack, Claire Hutchings, Williams Jack L.   +75 more
core   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Multi-epitope vaccine design for hepatitis E virus based on protein ORF2 and ORF3

Frontiers in Microbiology
IntroductionHepatitis E virus (HEV), with heightened virulence in immunocompromised individuals and pregnant women, is a pervasive threat in developing countries.
Qiong Lu, Hao Wu, Hao Wu, Jing Meng, Jiangyuan Wang, Jiajing Wu, Shuo Liu, Shuo Liu, Jincheng Tong, Jianhui Nie, Weijin Huang   +10 more
doaj   +1 more source

Selection and characterization of vaccine strain for Enterovirus 71 vaccine development

, 2012
[[abstract]]Enterovirus 71 (EV71) has recently emerged as an important neurotropic virus in Asia because effective medications and prophylactic vaccine against EV71 infection are not available.
Chang, JY;Chang, CP;Tsai, HH;Lee, CD;Lian, WC;Ih Jen, S;Sai, IH;Liu, CC;Chou, AH;Lu, YJ;Chen, CY;Lee, PH;Chiang, JR;Chong, PC
core   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Rational Design of Antigen Incorporation Into Subunit Vaccine Biomaterials Can Enhance Antigen-Specific Immune Responses

Frontiers in Immunology, 2020
Peptide subunit vaccines increase safety by reducing the risk of off-target responses and improving the specificity of the induced adaptive immune response. The immunogenicity of most soluble peptides, however, is often insufficient to produce robust and
Alexandra N. Tsoras, Kong M. Wong, Anant K. Paravastu, Julie A. Champion   +3 more
doaj   +1 more source