Results 91 to 100 of about 1,056,473 (318)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy

Molecules
Cyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years.
Liyan Yu, Hailiang Pan, Xiaohang Chen, Shan Gong, Qipeng Zhang, Yandong Zhang, Zhajun Zhan   +6 more
doaj   +1 more source

Marine Bioactive Peptides

In recent years, peptides generated from various marine organisms have attracted wide attention due to their diverse chemical structures and bioactivities, including antioxidant, immune-modulating, angiotensin-I-converting enzyme (ACE)-inhibitory ...

core   +1 more source

Synthesis of peptides for cancer cells targeting. An application to polyoxometalates delivery

, 2023
reservedIl mio elaborato di tesi si è svolto in due fasi. La prima è stata la sintesi di peptidi che agiscono come antagonisti di alcuni recettori sovraespressi in molte cellule cancerose.
BALICE, NICOLA
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product

Pharmaceutics
Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free alternatives under biosimilar or hybrid regulatory application.
Jimena Fernández-Carneado, Mariona Vallès-Miret, Sílvia Arrastia-Casado, Ana Almazán-Moga, Maria J. Macias, Pau Martin-Malpartida, Marta Vilaseca, Mireia Díaz-Lobo, Mayte Vazquez, Rosa M. Sanahuja, Gemma Gambús, Berta Ponsati   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A peptide puzzle

eLife, 2018
Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
openaire   +3 more sources

Natriuretic Peptides [PDF]

, 2014
Natriuretic peptide includes some neurohormones, such as atrial natriuretic peptides (ANP), B-type natriuretic peptides (BNP), C-type natriuretic peptides (CNP) and dendroapsis natriuretic peptides (DNP).
Selim Demirtaş, İhsan Karaboğa, Turan Karaca   +2 more
core  

Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides

, 2005
The present work comparatively analyzes the interaction of alpha-MSH and its more potent and long-acting analog [Nle(4), D-Phe(7)]alpha-MSH (NDP-MSH) with lipid bilayers.
Vieira, Renata de Freitas Fischer [UNIFESP], Ito, Amando Siuiti, Nakaie, Clovis Ryuichi [UNIFESP], Lamy, Maria Teresa, Fernandez, Roberto Morato   +4 more
core   +1 more source