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2022
This chapter describes the principles for selection of antigenic peptides for the development of anti-peptide antibodies suitable for microarray-based multiplex affinity assays and optional mass spectrometry detection. The methods described here are mostly applicable to small- and medium-scale multiplex affinity assay and microarrays. Although the same
Fan, Zhang +4 more
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This chapter describes the principles for selection of antigenic peptides for the development of anti-peptide antibodies suitable for microarray-based multiplex affinity assays and optional mass spectrometry detection. The methods described here are mostly applicable to small- and medium-scale multiplex affinity assay and microarrays. Although the same
Fan, Zhang +4 more
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PEPTIDE–WATER ASSOCIATION IN PEPTIDE CRYSTALS
International Journal of Peptide and Protein Research, 1979The structures of 37 peptide crystals, containing 78 water‐peptide hydrogen bonds and 77 other hydrogen bonds involving water, were surveyed to identify the geometry of peptide backbone hydration. In the sample, hydration of peptide carbonyl occurred more frequently than hydration of peptide N–H. The most probable value of the C'=0.
C H, Yang, J N, Brown, K D, Kopple
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Atrial natriuretic peptide and related peptides
Clinical Chemical Laboratory Medicine, 2007AbstractIn recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation.
Akashi, Yoshihiro J. +3 more
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1995
If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
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If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
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Crystal structures of peptides and modified peptides
Biopolymers, 1996The X-ray diffraction experiments on peptides and related molecules which have been carried out in Western Europe, except Italy, in the last eight years are reviewed. The crystal structures of some bioactive peptides such as Leu-enkephalin (a neurotransmitter), cyclosporin A (an immunomodulator in both the free and protein-bound state), balhimycin (an ...
M, Marraud, A, Aubry
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Life Sciences, 1973
Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Dissociation of the peptide bond in protonated peptides
Journal of Mass Spectrometry, 2000The dissociation of the amide (peptide) bond in protonated peptides, [M + H](+), is discussed in terms of the structures and energetics of the resulting N-terminal b(n) and C-terminal y(n) sequence ions. The combined data provide strong evidence that dissociation proceeds with no reverse barriers through interconverting proton-bound complexes between ...
M J, Polce, D, Ren, C, Wesdemiotis
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Non-peptide ligands for peptide receptors
Trends in Pharmacological Sciences, 1989Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Gastroenterology Clinics of North America, 1989
The intent of this article is to summarize the primary structures (that is, amino acid sequences) localization, primary gastrointestinal and pancreatic actions, and possible clinical relevance of the major gut peptides as well as some of the miscellaneous gut peptides. A brief overview of the general characteristics of gut peptides is presented.
D W, Green, G, Gomez, G H, Greeley
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The intent of this article is to summarize the primary structures (that is, amino acid sequences) localization, primary gastrointestinal and pancreatic actions, and possible clinical relevance of the major gut peptides as well as some of the miscellaneous gut peptides. A brief overview of the general characteristics of gut peptides is presented.
D W, Green, G, Gomez, G H, Greeley
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Peptides: Locally Active Peptides (“Vasoactive Peptides”)
1982Angiotensin may be considered the prototype of the so-called vasoactive peptides inasmuch as its predominant effect is on vascular smooth muscle, which is constricted by both direct and indirect effects of the peptide. However, angiotensin may affect contractility of much extravascular smooth muscle with a predominantly, if not exclusively, stimulatory
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