Results 161 to 170 of about 99,406 (260)

Enhancing the Antibacterial Activity of Endolysin against <i>Klebsiella pneumoniae</i> through Fusion Engineering Using Antimicrobial Peptide Sub5. [PDF]

J Microbiol Biotechnol
Gao K, Li Y, Wang Y, Zheng C, Zhu K, Mao X, Bai J, Hu R, Lei B, Hu S, Li X, Ni W.   +11 more
europepmc   +1 more source

Comparing Chemoenzymatic and Conventional Synthetic Strategies to Wall Teichoic Acid Peptidoglycan Fragments

Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.
The Gram‐positive bacteria, Staphylococcus aureus, contain wall teichoic acid (WTA, a glycopolymer (green and yellow)) is a virulence factor in their cell wall. Synthesis of the peptidoglycan‐(PG)‐WTA conjugate (blue squares) was developed via the phospho‐donor and PG acceptor (structures at the bottom right).
Min Liu, Kathleen C. Stathoulopoulos, Catherine Leimkuhler Grimes   +2 more
wiley   +1 more source

Chitosan/Gelatin Hydrogels With Hydroxyapatite/Silver Nanoparticles: A Dual Antimicrobial and Biocompatible Platform for Bone Regeneration

Journal of Applied Polymer Science, Volume 143, Issue 32, August 20, 2026.
Chitosan/gelatin hydrogels containing hydroxyapatite or hydroxyapatite/silver nanoparticles were developed and evaluated for bone tissue engineering applications, demonstrating biocompatibility and antimicrobial activity. ABSTRACT Bone tissue engineering demands multifunctional biomaterials capable of promoting regeneration while preventing local ...
Elisabeth Assis Martins Machado, Anne Caroline da Silva Rocha, Lívia Rodrigues de Menezes   +2 more
wiley   +1 more source

Chiral peptidoglycan mimics target bacterial wall biosynthesis for pathogen intervention. [PDF]

Nat Commun
Deng K, Zou D, Zeng Z, Guo B, Gong W, Xu Y, Li Y, Xu X.   +7 more
europepmc   +1 more source

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo, Jemma Gullick, Ryan F. Leung, Alex J. Fulcher, Rachel W. Cass, Julien Tailhades, Anton Y. Peleg, Jennifer A. E. Payne, Meredith O’Keeffe, Max J. Cryle   +9 more
wiley   +1 more source

Mutations in RNA polymerase that drive the emergence of antibiotic resistance. [PDF]

Curr Opin Microbiol
Patel Y, Helmann JD.
europepmc   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

BCG Induces PD-1 Upregulation on Circulating CD8⁺ T Cells and IL-6 and IL-8 Secretion <i>In Vitro</i>. [PDF]

Oncol Res
Barbosa GR, Dal Col LSB, Bighetto CC, de Godoy MCX, Campioni MDBP, Sadi MV, Gambero A, Reis LO.   +7 more
europepmc   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source