Results 21 to 30 of about 5,898 (109)

The 1.9 Å crystal structure of Escherichia coli MurG, a membrane‐associated glycosyltransferase involved in peptidoglycan biosynthesis [PDF]

Protein Science, 2000
AbstractThe 1.9 Å X‐ray structure of a membrane‐associated glycosyltransferase involved in peptidoglycan biosynthesis is reported. This enzyme, MurG, contains two α/β open sheet domains separated by a deep cleft. Structural analysis suggests that the C‐terminal domain contains the UDP‐GlcNAc binding site while the N‐terminal domain contains the ...
S, Ha, D, Walker, Y, Shi, S, Walker
openaire   +2 more sources

Direct interaction between MreB and the RodA‐PBP2 complex organizes lateral cell wall synthesis in Escherichia coli

mLife, EarlyView.
Abstract The elongasome, or the Rod complex, orchestrates lateral peptidoglycan (PG) synthesis in many rod‐shaped bacteria. It consists of the actin‐like protein MreB, the PG synthase RodA‐PBP2 complex, as well as MreCD and RodZ. Although the loss or disruption of any elongasome component results in a loss of rod shape, previous studies found that a ...
Rui Zhan, Han Gong, Ying Li, Xiangdong Chen, Joe Lutkenhaus, Shishen Du   +5 more
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Roles of PknB and CslA in Cell Wall Morphogenesis of Streptomyces

Molecular Microbiology, EarlyView.
Streptomyces grow by extending hyphal tips, a process regulated by polarisome complexes anchored by DivIVA. Using a genetic screen based on toxic DivIVA overproduction, we identified the kinase PknB as a key regulator of cell envelope construction.
Marta Derkacz, Andrew Watson, Akshada Gajbhiye, Michał Tracz, Dagmara Jakimowicz, Matthias Trost, Jeff Errington, Bernhard Kepplinger   +7 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli [PDF]

Molecular Microbiology, 2007
SummaryIn Escherichia coli many enzymes including MurG are directly involved in the synthesis and assembly of peptidoglycan. MurG is an essential glycosyltransferase catalysing the last intracellular step of peptidoglycan synthesis. To elucidate its role during elongation and division events, localization of MurG using immunofluorescence microscopy was
Mohammadi, T., Karczmarek, A., Crouvoisier, M., Bouhss, A., Mengin-Lecreulx, D., den Blaauwen, T.   +5 more
openaire   +4 more sources

Advances in Research on the Anti‐Tuberculosis Effects of Active Components in Chinese Herbal Medicine

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
This review summarizes how active constituents derived from Chinese herbal medicine exert anti‐tuberculosis (TB) effects via immunomodulation, direct inhibition of pathogens, and antioxidant activity. This synergistic, multi‐pathway mechanism highlights their potential as promising therapeutic candidates and adjunctive treatments against drug‐resistant
Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang   +8 more
wiley   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, Volume 109, Issue 5, May 2026.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source