Results 111 to 120 of about 5,729,531 (231)

Determination of Caries Lesion Activity: Reflection and Roughness for Characterization of Caries Progression

, 2018
SUMMARY Caries lesion progression is difficult to determine with visual and tactile examinations. The hypothesis of this study was that reflection and roughness measurements could determine caries progression.
Eckert, George J., S Shaikh, Shaikh, S., M Ando, G Eckert, Ando, Masatoshi   +5 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer in migrant populations: evidence from a regional oncology network

BMC Public Health
Cancer care for vulnerable populations such as migrants remains poorly investigated. The Campania Oncology Network (Rete Oncologica Campana, ROC) was established in Campania, a region of southern Italy, to ensure equitable access to cancer care.
Elisabetta Coppola, Chiara D’Alessio, Gabriele Calvanese, Laura Arenare, Davide D’Errico, Roberto Bianco, Fortunato Ciardiello, Michele Orditura, Ferdinando Riccardi, Stefano Pepe, Cesare Gridelli, Vincenzo Montesarchio, Gaetano Facchini, Bruno Daniele, Antonio Maria Grimaldi, Rosanna Ortolani, Filomena Sibilio, Luigi Leo, Bruno Marra, Rodolfo Cangiano, Annarita Roscigno, Elena Fossi, Tania Losanno, Francesca Palmieri, Alfredo Budillon, Paolo Chiodini, Francesco Perrone, Sandro Pignata   +27 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

NEW POSSIBILITIES OF SURGICAL CORRECTION OF POP WITH USE OF SYNTHETIC IMPLANTS: WAYS OF PREVENTIVE POSTOPERATIVE COMPLICATIONS

Акушерство, гинекология и репродукция, 2016
Per-operative and post-operative complications of polypropylene mesh surgery with synthetic systems are characterized in this article. The methods of complications prevention and management are described.
V. F. Bezhenar, E. V. Bogatyreva, A. A. Tscipurdeeva, L. K. Tsculadze, E. I. Rusina, E. S. Guseva   +5 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source