Results 71 to 80 of about 2,668,426 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lifestyle risk factor modification in midlife women with type 2 diabetes : theoretical modelling of perceived barriers [PDF]

, 2012
Objective:\ud The aim of this paper is to propose a ‘Perceived barriers and lifestyle risk factor modification model’ that could be incorporated into existing frameworks for diabetes education to enhance lifestyle risk factor education in women.\ud ...
McGuire, Amanda, McGuire, Amanda Mary, Anderson, Debra J., Anderson, Debra   +3 more
core   +1 more source

Perceived barriers in the use of ultrasound in developing countries [PDF]

Critical Ultrasound Journal, 2015
Abstract Background Access to ultrasound has increased significantly in resource-limited settings, including the developing world; however, there remains a lack of sonography education and ultrasound-trained physician support in developing countries.
Shah, Sachita, Bellows, Blaise A., Adedipe, Adeyinka A., Totten, Jodie E., Backlund, Brandon H., Sajed, Dana   +5 more
openaire   +2 more sources

Relationship between Perceived Benefits/Barriers and Decisional Balance with Stages of Change for Physical Activity among High School Students in Bandar Abbas

حیات, 2013
Background & Aim: This study aimed to assess relationship between perceived benefits/barriers and decisional balance with stages of change for physical activity among high school students in Bandar Abbas, Iran.
Teamur Aghamolaei, Sedigheh Sadat Tavafian, Amin Ghanbarnejad   +2 more
doaj  

Agency of smallholder cocoa farmers in the adoption system of fertilizer as agricultural innovation: a mixed methods study

Frontiers in Sustainable Food Systems
ContextSmall-scale cocoa farmers in central Côte d’Ivoire face low and declining cocoa productivity linked to poor soil health and climate. Yet, fertilizer use to sustain soil fertility in cocoa farming remains limited.ObjectiveThis study examines ...
Sibylle Lustenberger, Sibylle Lustenberger, Amit Aryal, Amit Aryal, Bognan Valentin Kone, Bassirou Bonfoh, Günther Fink, Günther Fink   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Knowledge, attitude and perceived barriers related to directly observed treatment, short-course among patients and caregivers attending tuberculosis clinics: a cross-sectional survey

Monaldi Archives for Chest Disease
Tuberculosis (TB) is a major worldwide health problem, particularly in India, where it accounts for a quarter of infections. Adherence to the directly observed treatment, short-course (DOTS), which is necessary for TB treatment, is difficult in resource-
Rakhi Gaur, Suresh Kumar Sharma, Suman Kumar, Shiv Kumar Mudgal, Vipin Patidar, Ayesha Juhi   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Perceived barriers to mental health care and goal setting among depressed, community-dwelling older adults

, 2009
Mark I Weinberger1, Camila Mateo2, Jo Anne Sirey11Department of Psychiatry, Weill Cornell Medical College, White Plains, NY, USA; 2College of Public Health and Health Professions, University of Florida, Gainesville, FL, USAObjective: Older ...
Jo Anne Sirey, Camila Mateo, Mark I Weinberger   +2 more
core