Results 111 to 120 of about 1,669,316 (384)

Effects of Different Low-Intensity Exercise Types on Duration, Energy Expenditure and Perceived Exertion in Obese Individuals [PDF]

, 2022
M. Khanfir, Hassen Ben Awicha, Liwa Masmoudi, Faten Ben Hmadou, Wajdi Dardouri, Sultan Alardan, Sabeur Nouira, Mohamed Zouch   +7 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

An investigative study into the influence of a commercially available carbohydrate-protein-electrolyte beverage on short term repeated exercise performance [PDF]

, 2012
Background: The purpose of this study was to undertake an independent investigation into the effects of ingesting a carbohydrate-protein-electrolyte (CPE) beverage on repeated submaximal and time-trial cycling performance. Methods: Sixteen recreationally
Kass, Lindsy, Roberts, Justin, Roberts, Michael G., Tarpey, Michael D.   +3 more
core   +4 more sources

Duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training session in female cross-country skiers

Frontiers in Physiology
PurposeThis study investigated duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training (LIT) session in female cross-country (XC) skiers.MethodsTwelve national-level female XC skiers (age:21.4 ± 2.7 ...
Per-Øyvind Torvik, Guro Strøm Solli, Rune Kjøsen Talsnes, Øyvind Sandbakk   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The effect of fructose and maltodextrin vs glucose and maltodextrin formulated sports beverages on mountain-bike race performance : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Sport and Exercise Science at Massey University, Wellington, New Zealand [PDF]

, 2007
Background: Exogenous carbohydrate improves performance during prolonged high-intensity exercise. When ingested together, fructose and glucose polymers are oxidised at rates 1.5-1.7 higher than isocaloric glucose solutions.
Swift, Marilla
core  

In-season internal and external training load quantification of an elite European soccer team [PDF]

, 2019
Elite soccer teams that participate in European competitions need to have players in the best physical and psychological status possible to play matches.
Brito, João, Ferraz, Ricardo, Marinho, Daniel A., Marques, Mário C., Martins, Alexandre, Mendes, Bruno, Oliveira, Rafael   +6 more
core   +2 more sources

THE RELEVANT USE OF A TRADITIONAL TUNISIAN GAME ‘‘RAQUASSA’’ FOR CARDIOVASCULAR SOLICITATION IN SCHOOL CHILDREN

Biology of Sport, 2013
Objective: The purpose of this study was to assess whether a lesson of physical activity based on a traditional Tunisian game could be a useful tool for soliciting the cardiovascular system in children.
Johnny Padulo, Mohamed Elloumi, Wassim Moalla, Tarak Jebali   +3 more
doaj   +1 more source