Results 91 to 100 of about 1,525,369 (288)

A comparison of AME and CR100 for scaling perceived exertion

Acta Psychologica, 2002
In psychophysical studies of the relation between perceived magnitude and physical stimulus, interest has focused on the preciseness of growth functions. Very little interest has been devoted to natural levels of an "absolute" character and to the validity of direct measurements.
Elisabet, Borg, Gunnar, Borg
openaire   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The validity and reliability of a rating scale of perceived exertion

Medicine & Science in Sports & Exercise, 1973
ABSTRACTIn order to test the validity of Borg's rating scale of perceived exertion, 8 lean and 8 obese subjects participated in a study to determine whether they could perceive small differences in work intensity when the work loads were presented in a random order.
J S, Skinner, R, Hutsler, V, Bergsteinová, E R, Buskirk   +3 more
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

No Detectable Effect of Caffeine Expectancy Induced by a Placebo Capsule on Time to Exhaustion at the Respiratory Compensation Point in Trained Cyclists

Sports
This study aimed to analyze the placebo effect associated with caffeine ingestion on cycling performance at the respiratory compensation point (RCP). Nineteen trained male cyclists (age: 28.1 ± 9.4 years; body mass: 71.0 ± 8.4 kg; VO2max: 67.1 ± 6.7 mL ...
Fernando Valero, Fernando González-Mohíno, Alejandro Alda-Blanco, Violeta Muñoz de la Cruz, Sergio Rodríguez-Barbero, Miguel Ángel Galán-Rioja, Juan José Salinero   +6 more
doaj   +1 more source

Can load carriage system weight, design and placement affect pain and discomfort? A systematic review [PDF]

, 2011
Purpose: A systematic review of the literature was conducted to answer the following questions: 1. Does usage or weight of load carriage system cause pain, perceived exertion or discomfort? 2.
Golriz, S., Walker, B.
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

ESTIMATING CALORIC EXPENDITURE USING THE PHYSICAL ACTIVITY INDEX (PAI) IN CHILDREN AND ADOLESCENTS PERFORMING A MULTISTAGE MAXIMAL EXERCISE TEST [PDF]

, 2014
PURPOSE: The primary purposes of this investigation were (a) to examine the validity of the PAI, (b) to develop a statistical model to predict cumulative Kcal expenditure using PAI as the predictor variable and (c) to develop a statistical model to ...
Gairola, Anjuli
core