Results 81 to 90 of about 1,525,369 (288)

Comparison of the electrical activity in upper trapezius and wrist extensor muscles during two typewriting conditions

Fisioterapia em Movimento
Introduction The proper use of the position of the arm and wrist while typing may reduce muscle overload and prevent musculoskeletal disorders.Objective To evaluate the electromyographic activity of upper trapezius and wrist extensor muscles during two ...
João Carlos Comel, João Pedro Batista Junior, Eliana Paula Chini, Hugo Maxwell Pereira, Rodrigo Luiz Carregaro, Jefferson Rosa Cardoso   +5 more
doaj   +1 more source

Hemodynamic and respiratory variation in the six-minute walk test in patients undergoing cardiac surgery: a cross-sectional study [PDF]

Fisioterapia e Pesquisa
The six-minute walk test (6MWT) is commonly prescribed for cardiac surgery patients, yet the hemodynamic and respiratory variations during the test remain insufficiently described in this population.
Julia Casagrande, Emely Teixeira Bodnar, Eliane Roseli Winkelmann   +2 more
doaj   +1 more source

Caffeine ingestion, affect and perceived exertion during prolonged cycling

, 2011
Caffeine's metabolic and performance effects have been widely reported. However, caffeine's effects on affective states during prolonged exercise are unknown. Therefore, this was examined in the present study.
Williams, C, Biddle, Stuart J. H., Backhouse, Susan H, Backhouse, SH, Susan H. Backhouse, Bishop, Nicolette C., Stuart J.H. Biddle, Williams, Clyde, Clyde Williams, Backhouse, Susan H., Biddle, Stuart, Nicolette C. Bishop, Bishop, NC   +12 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Use of actigraphy to measure real-world physical activities in manual wheelchair users

Journal of Rehabilitation and Assistive Technologies Engineering, 2020
Introduction The benefits of physical activity for manual wheelchair users are well-known. The purpose of this study was to validate actigraphy to objectively measure physical activity intensity among manual wheelchair users.
Sophie Bourassa, Krista L Best, Maxence Racine, Jaimie Borisoff , Jean Leblond, François Routhier   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Time-of-day effects on blood lactate levels following the Wingate anaerobic test in trained women athletes

BMC Sports Science, Medicine and Rehabilitation
This study aimed to examine the effect of time of day on anaerobic performance, blood lactate responses, and perceived exertion following the Wingate Anaerobic Test in trained women athletes engaged in regular resistance training. Twenty-one participants
Yakup Köse, Mehmet Ulaş, Hakan Büyükçelebi, Ulaş Sadık Bardakçı   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source