Results 61 to 70 of about 1,525,369 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Investigation of Interaction Effects of Elbow and Wrist Angles in Sitting and Standing Postures on Grip Strength and Perceived Exertion [PDF]

بهداشت و ایمنی کار
Introduction: Biomechanical risk factors, including wrist and elbow angle and standing and sitting position, are the primary factors affecting hand grip strength and perceived exertion.
Davood Afshari, Niloofar Chinisaz, Maryam Seyedtabib, Iman Dianat, Maryam Nourollahi-Darabad   +4 more
doaj  

Lung function and ventilatory response during high-intensity treadmill walking in adults with cerebral palsy: a cross-sectional study

Journal of Rehabilitation Medicine
Objective: To investigate lung function and ventilatory response during cardiopulmonary exercise testing in adults with cerebral palsy and assess the relationship between perceived breathlessness and breathing reserve at maximal exertion.
Eivind Lundgaard, Hanna Kraggerud, Charlotta Hamre, Matthijs Wouda   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Perceived exertion, comfort and working technique in professional computer users and associations with the incidence of neck and upper extremity symptoms

BMC Musculoskeletal Disorders, 2012
Background The aim of this study was to investigate whether perceived exertion, perceived comfort and working technique is associated with the incidence of neck and upper extremity symptoms among professional computer users.
Lindegård Agneta, Wahlström Jens, Hagberg Mats, Vilhelmsson Rebecka, Toomingas Allan, Wigaeus Tornqvist Ewa   +5 more
doaj   +1 more source

Impact of Centre-of-Mass Acceleration on Perceived Exertion, the Metabolic Equivalent and Heart Rate Reserve in Triathlete Spin Cycling: A Pilot Study

, 2022
Indoor spin cycling has gained popularity as a training modality for triathletes. Part of its appeal is that it can form a component of a structured periodised training program and provide an alternative to outdoor cycling.
Evans, SA, James, DA, Rowlands, D, Lee, JB   +3 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

How strenuous is esports? Perceived physical exertion and physical state during competitive video gaming

Frontiers in Sports and Active Living
IntroductionEsports or competitive video gaming is a rapidly growing sector and an integral part of today's (youth) culture. Esports athletes are exposed to a variety of burdens, that can potentially impact an athlete's health and performance. Therefore,
Chuck Tholl, Markus Soffner, Ingo Froböse   +2 more
doaj   +1 more source

Perceived effort of funtional activities after a period of mechanical ventilation

South African Journal of Physiotherapy, 2002
A case report to assess exercise testing post-mechanical ventilation, using functional activities while monitoring changes in the physiological parameters and subjective rating of perceived exertion.
R. Roos, H. van Aswegen, C. J. Eales
doaj   +1 more source