Results 71 to 80 of about 51,431 (308)

Exploring adaptations to the modified shuttle walking test [PDF]

, 2013
Objective: The 10 m modified shuttle walking test (MSWT) is recommended to determine the functional capacity in older individuals and for patients entering cardiac rehabilitation.
Steve Meadows, Kate Woolf-May, Meadows, S., Woolf-May, Kate, Meadows, Steve, Woolf-May, K.   +5 more
core   +1 more source

Scale of perceived exertion as injury prevention tool for young football players

Спортивная медицина: наука и практика
Objective: evaluation of the feasibility of using the Borg CR10 perceived exertion scale in the training process of young football players and its role in injury prevention.Material and methods: 48 athletes aged 15–17 were examined by scale of perceived ...
A. V. Borisova, F. V. Takhavieva, M. M. Kuznetsova, I. S. Dolgalev, Y. I. Preobrazhensky, Z. O. Shabanova, E. A. Malyakina, M. S. Butovsky   +7 more
doaj   +1 more source

Use of aquatic environment for assessing functional tests: feasibility, benefits, and challenges compared to land-based tests [PDF]

Fisioterapia e Pesquisa
: This study aimed to investigate the feasibility, benefits, and challenges of using aquatic environment to assess physical function tests compared with land-based assessments.
Gustavo Christofoletti, Anna Julia Santana Ribeiro, Maria Fernanda de Souza Macedo, Gabriela Maria da Silva Béé, Sidney Afonso Sobrinho-Junior, Jefferson Rosa Cardoso   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perceived exertion, comfort and working technique in professional computer users and associations with the incidence of neck and upper extremity symptoms

BMC Musculoskeletal Disorders, 2012
Background The aim of this study was to investigate whether perceived exertion, perceived comfort and working technique is associated with the incidence of neck and upper extremity symptoms among professional computer users.
Lindegård Agneta, Wahlström Jens, Hagberg Mats, Vilhelmsson Rebecka, Toomingas Allan, Wigaeus Tornqvist Ewa   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Investigation of Interaction Effects of Elbow and Wrist Angles in Sitting and Standing Postures on Grip Strength and Perceived Exertion [PDF]

بهداشت و ایمنی کار
Introduction: Biomechanical risk factors, including wrist and elbow angle and standing and sitting position, are the primary factors affecting hand grip strength and perceived exertion.
Davood Afshari, Niloofar Chinisaz, Maryam Seyedtabib, Iman Dianat, Maryam Nourollahi-Darabad   +4 more
doaj  

Perceived effort of funtional activities after a period of mechanical ventilation

South African Journal of Physiotherapy, 2002
A case report to assess exercise testing post-mechanical ventilation, using functional activities while monitoring changes in the physiological parameters and subjective rating of perceived exertion.
R. Roos, H. van Aswegen, C. J. Eales
doaj   +1 more source