Results 281 to 290 of about 2,850,818 (357)

Self-perceived quality of life, cognitive and behavioural impairment in amyotrophic lateral sclerosis. [PDF]

J Neurol
Radakovic R, Carroll A, Altiero A, Reichwein C, Walsh S, Niven E, Abrahams S, Simmons Z.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Oral health manifestations and the perceived quality of life among Saudi children: a cross-sectional study. [PDF]

PeerJ
Sabbagh HJ, Abudawood SN.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Is It Possible to Improve the Perceived Quality of Life of Overweight or Obese Older People through a Multicomponent Physical Exercise Program? [PDF]

Behav Sci (Basel)
Pleticosic-Ramírez Y, Arufe-Giráldez V, Rodríguez-Negro J, Mecías-Calvo M, Navarro-Patón R.   +4 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

A multimodal intervention program to improve sexual health and self-perceived quality of life in patients treated for cervical cancer: a randomized prospective study (PROVIDENCE trial). [PDF]

J Gynecol Oncol
Gil-Ibañez B, Carreras-Dieguez N, López G, Sánchez-Hoyo B, Nuño BC, Oliver-Perez R, Castelo-Branco C, Marina T, Torné A, Tejerizo A, Diaz-Feijoo B.   +10 more
europepmc   +1 more source

Mediating Roles of Perceived Quality and Perceived Behaviour Control in Shaping Chinese Consumer's Purchase Intention for Domestic Infant Milk Formula (IMF). [PDF]

Foods
Zhang J, Waldron S, Dong X, Dai X.
europepmc   +1 more source