Results 121 to 130 of about 2,699,721 (304)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

The Relationship Between Nomophobia, Perceived Stress, and Perceived Social Support Among Medical Students at Mazandaran University of Medical Sciences in 2023 [PDF]

open access: yesJournal of Mazandaran University of Medical Sciences
Background and purpose: The use of smartphones has significantly increased among students. Although this technology offers various benefits, its misuse can lead to negative consequences, such as nomophobia.
Saeed Barzegari   +5 more
doaj  

Association between perceived social support and anxiety in pregnant adolescents

open access: yesBrazilian Journal of Psychiatry
Objective: To evaluate the association between perceived social support and anxiety disorders in pregnant adolescents. Methods: We conducted a cross-sectional study with a sample of 871 pregnant women aged 10 to 19 years who received prenatal care in ...
Patrícia J. Peter   +8 more
doaj   +1 more source

Relationship of Psychological Well-Being With Perceived Stress, Coping Styles, and Social Support Amongst University Undergraduates [PDF]

open access: yes, 2000
The psychological well-being of undergraduates in Malaysia in relation to their perceived stress, coping styles, and social support has not been thoroughly investigated.
Annette, Ananthi Arulrajah
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Comparing Perceived Social Support and Perceived Stress in Women with and without Polycystic Ovary Syndrome Refereed to Fatemiyeh Hospital in Hamadan City

open access: yesپژوهان, 2018
Background and Objectives: Polycystic Ovary Syndrome is a common issue that affects womens in pregnant age and international statistics indicate that this syndrome is increasing. The aim of this study was to compare perceived social support and perceived
Fatemeh Shobeiri   +3 more
doaj  

Influence of perceived social support on detection of social norm violation: evidence from N1 and N400

open access: yesFrontiers in Psychology
IntroductionThe perceived social support individuals receive from their others plays a crucial role in shaping conformity with social norms. However, the specific mechanism underlying perceived social support and the detection of social norms remains ...
Bing Liang   +5 more
doaj   +1 more source

The Effect of Motivations on Social Indirect Reciprocity: an Experimental Analysis [PDF]

open access: yes
This paper investigates the effects of motivations on the perceived kindness of an action within the context of strong social indirect reci- procity. We test experimentally the hypothesis that, for a given dis- tributional outcome, an action is perceived
Luca Stanca   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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