Results 121 to 130 of about 659,643 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comparing Perceived Social Support and Perceived Stress in Women with and without Polycystic Ovary Syndrome Refereed to Fatemiyeh Hospital in Hamadan City

پژوهان, 2018
Background and Objectives: Polycystic Ovary Syndrome is a common issue that affects womens in pregnant age and international statistics indicate that this syndrome is increasing. The aim of this study was to compare perceived social support and perceived
Fatemeh Shobeiri, Maryam Ataollahi, Safoura Jahanara, Ghodratollah Roshanaei   +3 more
doaj  

Investigation of the Resilience, Self-Efficacy, and Perceived Social Support of Gifted Students

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Özel Eğitim Dergisi
Introduction: This research aimed to analyze the levels of psychological resilience in terms of different variables, self-efficacy, and perceived social support among gifted students, investigate the relationships between these variables, and examine the
Ayşegül Kılıçaslan Çelikkol, Özge Yıldırım   +1 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Systematic review and qualitative meta-synthesis on social capital and active outdoor play: Relationships and impacts

Wellbeing, Space and Society
Active outdoor play supports overall health and well-being for all ages. Social capital is known to associate with outdoor play; however, these relationships are likely complex. This systematic review and meta-synthesis aimed to clarify the relationships
Eun-Young Lee, Seiyeong Park, Alethea Jerebine, Michael Down, Uk Kim, Joy Cheng, Sangeetha Saravanan, Leanne Abungin, Yeong-Bae Kim, Louise de Lannoy, Taru Manyanga, Amanda Ross-White, Leigh M. Vanderoo, Kyoung June Yi, Mark S. Tremblay   +14 more
doaj   +1 more source

Drivers of service recovery performance: perceived organisational support, learning and psychological job outcomes [PDF]

Service recovery is an under-researched area in theoretical and empirical terms (Smith, Bolton, and Wagner 1999). In particular, limited knowledge exists regarding the factors which have an impact on the service recovery performance of frontline ...
Lages, Cristiana Raquel Costa
core  

Relationship between proactive personality, perceived social support, and career decision making self-efficacy among final-year students in public universities of Selangor [PDF]

Studying career decision-making self-efficacy among final-year students is crucial because it affects students' readiness and confidence in making informed career choices.
Sivanesan, Nithyalakshmi, Mohd Khir, Azlina   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Perceived social support on objective measured sedentary behavior of stroke patients: the mediating role of exercise self-efficacy

Frontiers in Psychology
IntroductionAs stroke patients may have impaired motor function, there may have increased sedentary behavior. Factors associated with sedentary behavior need to be explored to develop targeted interventions.
Jianing Wei, Fanjiayi Yang, Xiaofang Dong   +2 more
doaj   +1 more source