Results 101 to 110 of about 1,602,570 (311)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Associations of perceived prenatal stress and adverse pregnancy outcomes with perceived stress years after delivery

Archives of Women's Mental Health, 2019
Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal stress years after pregnancy. The 10-item Perceived Stress Scale (PSS) (0-40 range) was completed in the first and third trimesters, and 2-7 years after delivery among a subsample (n = 4161) of ...
Monk, Catherine, Webster, Rachel S, McNeil, Rebecca B, Parker, Corette B, Catov, Janet M, Greenland, Philip, Bairey Merz, C Noel, Silver, Robert M, Simhan, Hyagriv N, Ehrenthal, Deborah B, Chung, Judith H, Haas, David M, Mercer, Brian M, Parry, Samuel, Polito, LuAnn, Reddy, Uma M, Saade, George R, Grobman, William A   +17 more
openaire   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The influence of effort-reward imbalance and perceived organizational support on perceived stress in Chinese nurses: a cross-sectional study

BMC Nursing
Background The nursing profession is characterized by high intensity and significant stress. Nurses must not only manage heavy workloads but also address diverse patient needs, engage in emotional labor, and cope with occupational exposure risks.
Yajie Shi, Linying Wang, Junyan Zhang, Junkang Zhao, Juyi Peng, Xianmei Cui, Wanling Li   +6 more
doaj   +1 more source

A Randomized Controlled Trial of Device Guided, Slow-Paced Respiration in Women with Overactive Bladder Syndrome. [PDF]

, 2019
PurposeWe evaluated the effects of device guided, slow-paced respiration on urgency associated urinary symptoms, perceived stress and anxiety, and autonomic function in women with overactive bladder syndrome.Materials and methodsWe performed a randomized,
Grady, Deborah, Hernandez, Cesar, Huang, Alison J, Mendes, Wendy B, Schembri, Michael, Subak, Leslee L   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Perceived Stress and Associated Factors Among Pregnant Women Attending Antenatal Care in Urban Thailand

Psychology Research and Behavior Management, 2020
Wassapol Thongsomboon,1 Kasemsis Kaewkiattikun,1 Nitchawan Kerdcharoen2 1Department of Obstetrics & Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand; 2Department of Psychiatry, Faculty of Medicine Vajira
Thongsomboon W, Kaewkiattikun K, Kerdcharoen N   +2 more
doaj  

Self-Affirmation Improves Problem-Solving under Stress [PDF]

, 2013
High levels of acute and chronic stress are known to impair problem-solving and creativity on a broad range of tasks. Despite this evidence, we know little about protective factors for mitigating the deleterious effects of stress on problem-solving ...
A Martens, A McQueen, A Miyake, AFT Arnsten, AM Isen, BA Nijstad, C Liston, C Liston, C Martindale, CJ Wakslak, CM Steele, CM Steele, D Watson, DK Sherman, DK Sherman, E Bowden, E Bowden, G Rowe, GL Cohen, GL Cohen, J Blascovich, J Crocker, J. David Creswell, Janine M. Dutcher, JD Creswell, JD Creswell, JK Alexander, John M. Levine, José César Perales, JP Jamieson, KS Bowers, M Jung-Beeman, Peter R. Harris, RA Dienstbier, RJ Benschop, RM Baron, S Cohen, S Cohen, S Mednick, S Sandkühler, SL Beilock, T Schmader, William M. P. Klein   +42 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Perceived Stress and Burnout: The Mediating Role of Self-Care and Job Satisfaction as Preventive Factors in Helping Professions

European Journal of Mental Health, 2020
Monika Hricova, Jana Nezkusilova, Beata Raczova   +2 more
doaj   +1 more source