Results 121 to 130 of about 8,966,850 (291)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Exploring the Relationship between Childhood Interpersonal Violence, Cortisol Stress Response, and Stress Eating [PDF]

, 2013
Histories of childhood interpersonal violence have been linked to overweight and obesity in adulthood. Despite the fact that victimization experiences are likely to co-occur within individuals, few studies have examined poly-victimization in the context ...
Midei, Aimee J
core  

Effect of Tai Chi Practice on Stress, Self-Esteem, and Perceived Life Expectancy and a Structural Model of Relation Among These Variables Taking Into Account Age

SAGE Open, 2014
The aims of this article were to (a) investigate whether practicing Tai Chi has an effect on stress, self-esteem, and perceived life expectancy and (b) contrast a structural model of relation between the three latter variables taking into account age ...
José Moral de la Rubia, Adrian Valle de la O, Cirilo H. García Cadena, Luis A. Pérez Góngora   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Role of Academic Burnout, Resilience, and Perceived Stress in Predicting Students\' Addiction Potential [PDF]

Research on Addiction, 2015
Objective: This study aimed at determining the role of academic burnout, resilience, and perceived stress in predicting students;#39 addiction potential.
mojtaba salmabadi, Hossein Salimi Bajestani, hamze Khayami Abiz, Reza javan   +3 more
doaj   +2 more sources

Self-esteem and learning engagement among Chinese middle school students: a moderated mediation model

Психологическая наука и образование
Context and relevance. Learning engagement is a positive, fulfilling state of mind related to learning. Amid growing academic and psychological pressures, exploring its psychological foundations in junior high school students is essential ...
Z. Li, L. Wang, W. Fan, M. Cheng, W. Sun, Z. Yang   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Effect of Perceived Stress on Insomnia Symptoms Among College Students: A Moderated Mediation Model [PDF]

Zengyan Lu, Yangjin Li, Zhihao Yan, Qingsong Sang, Wenqiang Sun College of Educational Science, Anhui Normal University, Wuhu, People’s Republic of ChinaCorrespondence: Wenqiang Sun; Qingsong Sang, College of Educational Science, Anhui Normal University,
Li Y, Yan Z, Sang Q, Lu Z, Sun W
core  

Effects of Jacobson Relaxation Exercises and Deep Breathing Exercises on Post Menopausal Stress and Quality of Life

Фізична реабілітація та рекреаційно-оздоровчі технології
Purpose. Post-menopausal women have increased stress and decreased well-being as a result of hormonal imbalance, physical discomfort, and mood change. Jacobson relaxation and deep breathing exercises, though identified to decrease stress, their efficacy
Priyanka Bai, Saravankumar J., S. Dhanusia, Mohamed Sahal   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source