Results 101 to 110 of about 263,151 (246)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of the psychometric properties of the Italian version of the 10-item perceived stress scale in a sample of teachers. [PDF]

Front Psychol, 2023
Messineo L, Tosto C.
europepmc   +1 more source

Permission for use of Perceived Stress Scale

Permission for use of the perceived stress scale.
openaire   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The Mediating Role of Person Organization Fit in the Effect of Perceived Organizational Support in Nurses Working at a University Hospital on Work Stress

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: To investigate the mediating role of person-organization fit in the effect of perceived organizational support in nurses on job stress. Method: The sample of the study consisted of 500 nurses working at a university hospital in Eskişehir (N = 923 ...
Merve Özlü, Aysun Türe
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Psychometric validation of the Perceived Stress Scale (PSS-10) among family caregivers of people with schizophrenia in China. [PDF]

BMJ Open, 2023
Xiao T, Zhu F, Wang D, Liu X, Xi SJ, Yu Y.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Perceived stress and sleep quality in young and middle-aged patients with coronary heart disease: the mediating role of perceived social support and mental health literacy

Frontiers in Psychology
BackgroundGlobally, there is an increasing emphasis on mental health, particularly its role in the recovery of patients with coronary heart disease (CHD).
Ying Lu, Juan Li, Zhenzhen Cui, Mengzhen Zheng, Yuqin Zhao   +4 more
doaj   +1 more source