Results 91 to 100 of about 263,151 (246)

Self-esteem and learning engagement among Chinese middle school students: a moderated mediation model

Психологическая наука и образование
Context and relevance. Learning engagement is a positive, fulfilling state of mind related to learning. Amid growing academic and psychological pressures, exploring its psychological foundations in junior high school students is essential ...
Z. Li, L. Wang, W. Fan, M. Cheng, W. Sun, Z. Yang   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Investigate the Mediating Role of Parentification in the Relationship between Boundary Ambiguity with Family Support, Family Satisfaction and Perceived Stress in Adolescent Girls of Divorced Families

فصلنامه خانواده پژوهی, 2019
The purpose of this study was to investigate the mediating role of parentification in the relationship between boundary ambiguity with family support, family satisfaction, and perceived stress in adolescent girls in divorce families.
مهتاب دانایی, اعظم فرح بیجاری, لیلا چراغ ملایی   +2 more
doaj  

Effects of Jacobson Relaxation Exercises and Deep Breathing Exercises on Post Menopausal Stress and Quality of Life

Фізична реабілітація та рекреаційно-оздоровчі технології
Purpose. Post-menopausal women have increased stress and decreased well-being as a result of hormonal imbalance, physical discomfort, and mood change. Jacobson relaxation and deep breathing exercises, though identified to decrease stress, their efficacy
Priyanka Bai, Saravankumar J., S. Dhanusia, Mohamed Sahal   +3 more
doaj   +1 more source

Psychometric testing of the 10-item perceived stress scale for Chinese nurses. [PDF]

BMC Nurs, 2023
Du X, Liu X, Zhao Y, Wang S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Perceived Stress Scale (PSS) survey questionnaire

, 2019
Perceived Stress Scale (PSS) survey ...
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source