Results 71 to 80 of about 278,176 (329)

Mediating Role of Perceived Stress in the Relationship between Facing Existential Issues and Symptoms of Depression and Anxiety

open access: yesIranian Journal of Psychiatry, 2020
Objective: This study aimed at investigating the mediating role of perceived stress in anticipation of anxiety and depression on facing the ultimate concerns (death, loneliness, freedom, and meaningfulness).
Mohammad-Ali Besharart   +3 more
doaj   +1 more source

An exploratory study of the effects of mindfulness on perceived levels of stress among school-children from lower socioeconomic backgrounds [PDF]

open access: yes, 2014
Children from lower socioeconomic backgrounds are at increased risk of experiencing stress and associated social-emotional difficulties and behavioural problems, which can undermine academic performance and lead to school drop-out.
Lawler, Margaret   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Physiological and psychological recovery from muscle disruption following resistance exercise : the impact of chronic stress and strain [PDF]

open access: yes, 2009
textA large body of evidence supports the notion that chronic stress and strain may impact healing from physical trauma. However, no evidence exists to substantiate whether chronic stress impacts recovery from exercise-induced muscle damage.
Stults, Matthew Alan
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PERCEPTION OF “STRESS” AND “STRESSORS”AMONG FIRST YEAR MEDICAL STUDENTS AND EFFECT OF INTERVENTION ON THEIR STRESS PERCEPTION

open access: yesPakistan Armed Forces Medical Journal, 2020
Objective: To explore perception of stress & stressors among first year medical students, with or without intervention. Study Design: Quasi-experimental study. Place and Duration of Study: Shaheed Mohtarma Benazir Bhutto Medical University (SMBBMU),
Dr Aisha
doaj  

Prevalence and Determinants of Perceived Stress among Undergraduate Respiratory Therapy Students in Saudi Arabia

open access: yes
Background: Stress is a common phenomenon among health sciences students, severely impacting students in different ways. Similar to other students, undergraduate Respiratory Therapy (RT) students are at a high risk of stress exposure that may harm their ...
Baogbah, Abdulmajeed
core   +1 more source

Device-measured Desk-based Occupational Sitting Patterns and Stress (hair cortisol and perceived stress) [PDF]

open access: yes, 2019
Background: Stress and poor mental health are significant issues in the workplace and are a major cause of absenteeism and reduce productivity. Understanding what might contribute towards employee stress is important for managing mental health in this ...
Gemma C. Ryde   +11 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy