Results 101 to 110 of about 74,207 (247)

Factors Influencing Telemedicine Adoption Among Healthcare Professionals in Geriatric Medical Centers: A Technology Acceptance Model Approach

Behavioral Sciences
Background: Telemedicine has gained significance, especially during the COVID-19 pandemic, offering remote healthcare solutions. However, its adoption in geriatric medical centers (GMCs) remains limited. Understanding the factors influencing telemedicine
Tammy Porat-Packer, Gizell Green, Cochava Sharon, Riki Tesler   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Influence Of Perceived Convenience, Perceived Useful-ness, And Perceived Risk On Interest In Using E-Commerce

Reviu Akuntansi, Keuangan, dan Sistem Informasi
The rapid development of information and communication technology has transformed how people perform activities, including business transactions. This study aims to analyze the influence of perceived ease of use, perceived usefulness, and perceived risk on the intention to use e-commerce.
Fikha Zahirah Taufik R., Lutfi Harris
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Factors Affecting Vietnamese Young People’s Impulsive Purchasing Intention on Live-Streaming Commerce

International Journal of Management, Finance and Accounting
This paper examines the factors affecting Vietnamese young people’s impulsive purchasing intention in the live-streaming commerce environment. Adopting the S-O-R research model with influencing factors is the Streamer’s Attractiveness (AT), Streamer’s ...
Thien My Ngo, Thi Mai Le
doaj   +1 more source

Analisis Perceived Ease of Use dan Perceived Usefulness Terhadap Actual System Use Aplikasi SAKTI

MANDAR: Management Development and Applied Research Journal
Penelitian ini bertujuan untuk menguji pengaruh perceived ease of use dan perceived usefulness terhadap actual system use aplikasi SAKTI di Direktorat Jenderal Perkeretaapian Kementerian Perhubungan. Metode penelitian yang digunakan adalah metode kuantitatif dengan teknik pengumpulan data melalui kuesioner. Analisis data menggunakan aplikasi smartPLS 4.
null Mediaty, Ratna Ayu Damayanti, Hidayat Harsudi, Riska Nur Indah Ramadany, Andi Aisyah   +4 more
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

PENGARUH TRUST, PERCEIVED USEFULNESS, PERCEIVED EASE OF USE, PERCEIVED RISK TERHADAP INTENTION TO USE APLIKASI INVESTASI ONLINE E-BROKERAGE

Jurnal Akuntansi dan Manajemen
This study aims to analyze the relationship between trust, perceived usefulness, perceived ease of use, perceived risk on the intention to use e-brokerage online investment applications. This research is a primary data and uses a quantitative descriptive method with a purposive sampling method, while the data collection technique in this study uses a ...
null Vira Yuniar Samsul, null Efraim Ferdinan Giri   +1 more
openaire   +1 more source