Results 81 to 90 of about 78,340 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Investigasi Faktor Yang Mempengaruhi Behavioral Intention Pada Pengguna Grab Bike

J-MKLI (Jurnal Manajemen dan Kearifan Lokal Indonesia), 2019
Tujuan penelitian ini mengetahui pengaruh behavioral intention (BI) terhadap transportasi online grab bike dengan menggunakan variabel trust, perceived ease of use (PEOU), perceived risk (PR) dan perceived usefulness (PU).
Sulaiman, Zainal Abidin, Suharno
doaj  

The Influence of Perceived Ease of Use and Perceived Usefulness on Switching Intention

Tourism Scientific Journal
Technology and the internet have brought substantial changes to the tourism industry, particularly through online travel agents (OTAs). One of the major challenges faced by OTA is the phenomenon of "switching intention," where consumers tend to move from one service provider to another. This behavior may result in customer loss and a decline in profits.
Gusti Ketut Oka Saputra, Oce Ridwanudin, Yeni Yuniawati   +2 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

HOW PERCEIVED EASE OF USE, TRUST, AND PERCEIVED USEFULNESS INFLUENCE TOURISTS’ DECISION TO BOOK HOMESTAY SERVICES ONLINE [PDF]

Geo Journal of Tourism and Geosites
This research aims to investigate the relationships between perceived ease of use, perceived usefulness, tourist trust, and online booking intention. 450 tourists around Thailand were invited to join this research via survey questionnaires.
Thanapa CHOUYKAEW, Long KIM*, Gulmira ISSAYEVA   +2 more
doaj   +1 more source

The Influence of Perceived Usefulness, Perceived Ease of Use, Perceived Risk, Trust on the Decision to Use QRIS as Digital Payment

International Journal of Business and Applied Economics
This study aims to analyze the influence of the perception of benefits, convenience, risks, and trust on the decision to use QRIS as a digital payment method. The research population is individuals in the Purwokerto area (East, West, North, South) who have digital payment applications and have used QRIS.
Mohamad Alfharizi Ramdhani, Arini Hidayah, Herni Justiana Astuti, Hengky Widhiandono   +3 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An extension of the technology acceptance model for understanding travelers' adoption of variable message signs.

PLoS ONE, 2019
Understanding travelers' acceptance of Advanced Traveler Information Systems (ATIS) is crucial to the implementation of Intelligent Transportation Systems (ITS) capable of mitigating traffic congestion and improving network performance.
El Bachir Diop, Shengchuan Zhao, Tran Van Duy   +2 more
doaj   +1 more source