Results 101 to 110 of about 78,689 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Factors Affecting Vietnamese Young People’s Impulsive Purchasing Intention on Live-Streaming Commerce

International Journal of Management, Finance and Accounting
This paper examines the factors affecting Vietnamese young people’s impulsive purchasing intention in the live-streaming commerce environment. Adopting the S-O-R research model with influencing factors is the Streamer’s Attractiveness (AT), Streamer’s ...
Thien My Ngo, Thi Mai Le
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Influence of Perceived Usefulness and Perceived Ease of Use on Online Purchase Intention Mediated by Perceived Enjoyment

East Asian Journal of Multidisciplinary Research
The study identify the influence of perceived usefulness and perceived ease of use on online purchase intention, both directly and indirectly through perceived enjoyment among 112 users of Sociolla's online channel in Denpasar City and Badung Regency, Bali Province, Indonesia.
I Made Pradnyana Adi Putra, Gede Suparna
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Determinants of personal accounting applications adoption: A perspective of the centennial generation

Jurnal Akuntansi dan Auditing Indonesia
This study aims to identify the factors influencing the intention to use a personal accounting application by employing the Technology Acceptance Model (TAM) and the Diffusion of Innovation (DOI) theory.
Selvi Saputri, Muamar Nur Kholid
doaj   +1 more source

PENGARUH PERCEIVED EASE OF USE DAN PERCEIVED USEFULNESS TERHADAP ACTUAL USE

Jurnal Kewirausahaan dan Inovasi
The purpose of this research is to discover and analyze the technology acceptance model (TAM), namely the influence of Perceived Ease of Use and Perceived Usefulness of Actual Use Ticket Vending Machine of MRT Jakarta. TAM is a technology acceptance theory that explains and estimates user acceptance of an information system.
Miftahul Huda, Nur Prima Waluyowati
openaire   +1 more source

The effect of perceived usefulness, perceived security, and trust on intention to use in mobile banking with perceived ease of use as a mediation variable

Edelweiss Applied Science and Technology
This study examines how Perceived Usefulness, Perceived Security, and Trust impact the intention to use mobile banking, with Perceived Ease of Use acting as a mediating variable. The research targets users of the BCA mobile banking app in Indonesia. This study employs a quantitative cross-sectional survey involving 140 BCA mobile users domiciled in ...
Michael Eliezer Prawira, Vinnie Stevianie, Rianto Nurcahyo   +2 more
openaire   +1 more source