Results 101 to 110 of about 6,718,749 (239)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A Super Efficiency Model for Product Evaluation [PDF]

This study applies a Super Efficiency Data Envelopment Analysis model to evaluate the efficiency of cars sold on the German market. Efficiency is conceptualized from a customers' perspective as a ratio of outputs that customers obtain from a product ...
Maik Hammerschmidt, Matthias Staat
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Water use efficiency and economic return of fresh vegetable in organic cultivation

Revista Brasileira de Engenharia Agrícola e Ambiental
The optimization in the use of irrigation is a necessity due to water scarcity and the increasing demand for food. The objective of this study was to evaluate the effect of different irrigation depths on the economic efficiency of lettuce, eggplant, beet
Daniel F. de Carvalho, Marinaldo F. Pinto, José A. Monte, Gabriel A. B. de Mello, Camila P. de Sousa   +4 more
doaj   +1 more source

Agricultural efficiency of rice farmers in Myanmar : a case study in selected areas [PDF]

This paper try to analyze unique data set for rice producing agricultural households in some selected areas of Bago and Yangon divisions to examine the households' profit efficiency and the relationship between farm and household attributes and profit ...
Nay Myo Aung
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A Resource of the National Action Plan for Energy Efficiency [PDF]

, 2009
This brief documents how energy efficiency program administrators have used technical, institutional, financial, and other resources to help advance building energy codes at the federal, state, and local levels, and describes the issues involved in ...
National Action Plan for Energy Efficiency, National Action Plan for Energy Efficiency (U.S.)   +1 more
core  

Temporal relationships of ecological efficiency with percent relative abundance for two functional feeding groups: (A) benthic invertivores, (B) planktivores.

, 2015
Temporal relationships of ecological efficiency with percent relative abundance for two functional feeding groups: (A) benthic invertivores, (B) planktivores.
Kyle J. Broadway (728409), Mark Pyron (728410), Brent A. Murry (728412), James R. Gammon (728411)   +3 more
core   +1 more source