Results 51 to 60 of about 12,038 (217)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Critical behavior of the multigel percolation model

Physical Review Research
In a recently introduced bond-percolation model, Sousa et al. [Phys. Rev. Res. 7, L022067 (2025)10.1103/PhysRevResearch.7.L022067] showed that multiple spanning clusters can coexist in three dimensions, with their number remaining unbounded in the ...
Carlos G. L. Sousa, José S. Andrade, Jr., Cesar I. N. Sampaio Filho, Erika Eiser, Alex Hansen, Hans J. Herrmann, André A. Moreira   +6 more
doaj   +1 more source

Conductivity and permittivity of dispersed systems with penetrable particle-host interphase

Condensed Matter Physics, 2013
A model for the study of the effective quasistatic conductivity and permittivity of dispersed systems with particle-host interphase, within which many-particle polarization and correlation contributions are effectively incorporated, is presented.
M.Ya. Sushko, A.K. Semenov
doaj   +1 more source

Features of charge transport in polymer composites polymethylmethacrylate - polyaniline

Фізика і хімія твердого тіла, 2020
The influence of polymer matrix of polymethyl methacrylate (PMMA) on the specific conductivity, percolation threshold, energy of activation of charge transport in polymer composites PMMA − polyaniline (PAN) was studied. Concentration dependence of the
G. V. Martynyuk, O. I. Aksimentyeva
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Modelling of conduction degradation kinetics in nanostructured low-dimensional semiconductor layers under long-term DC exposure [PDF]

Известия Саратовского университета. Новая серия: Физика
Background and Objectives: Percolation models are widely employed to analyze electrical transport in disordered systems, particularly near critical thresholds. While substantial research has focused on static percolation properties, the dynamic evolution
Kochkurov, Leonid Alekseevich
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Dielectric percolation in ceramic matrix composites

Journal of Advanced Dielectrics
This paper presents the results of an experimental study of the percolation behavior of the complex dielectric constant of ceramic matrix composites (CMC). Samples of piezoactive CMC were obtained by joint sintering of synthesized PZT piezoceramic powder
A. N. Rybyanets, N. A. Shvetsova, I. A. Shvetsov, N. A. Kolpacheva   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source