Results 31 to 40 of about 177 (87)
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Recent genome‐wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case‐control datasets of SNPs variants located at 1p13.
Francisco Rodríguez Esparragón +4 more
wiley +1 more source
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo +6 more
wiley +1 more source
CellSs: Scheduling Techniques to Better Exploit Memory Hierarchy
Cell Superscalar′s (CellSs) main goal is to provide a simple, flexible and easy programming approach for the Cell Broadband Engine (Cell/B.E.) that automatically exploits the inherent concurrency of the applications at a task level. The CellSs environment is based on a source‐to‐source compiler that translates annotated C or Fortran code and a runtime ...
Pieter Bellens +5 more
wiley +1 more source
Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon +4 more
wiley +1 more source
ABSTRACT Aims To identify and evaluate the magnitude of the association between caregiver psychosocial factors and depressive symptoms among people with dementia. Design Systematic review and meta‐analysis. Methods A systematic review with meta‐analysis used a random‐effects model to estimate the effect size.
Wenjing Ning +3 more
wiley +1 more source
Abstract INTRODUCTION Proteins interacting with amyloid beta (Aβ) fibrils could be key to plaque formation in Alzheimer's disease (AD) and represent potential biomarkers and therapeutic targets. Previous proteomic studies using microdissected plaques might have captured non‐specific components rather than true Aβ interactors.
Ana Montero‐Calle +10 more
wiley +1 more source
Las transferencias intergubernamentales en México, objetivos, implementación e impacto en el esfuerzo fiscal de los gobiernos locales: un acercamiento teórico [PDF]
The research focuses on analyzing, from the theory of fiscal federalism, the harmonization and correspondence of the relationships that intergovernmental transfers have: with the rent distribution function (income) and the resource allocation function ...
Gómez Monge, Rodrigo +1 more
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Abstract INTRODUCTION Cut‐offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut‐offs across sites.
Laura del Hoyo Soriano +21 more
wiley +1 more source
Pereza fiscal: costos y beneficios de incrementar la recaudación en los municipios mexicanos [PDF]
La presente investigación busca determinar si el federalismo fiscal en México genera los incentivos suficientes para que los municipios dejen de ser perezosos, para esto se analizarán los costos en que incurrirían los municipios para cerrar la brecha ...
Toledo Toledo, Dalia
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