Results 31 to 40 of about 15,381 (219)

The HIE-FDTD Method for Simulating Dispersion Media Represented by Drude, Debye, and Lorentz Models

Nanomaterials, 2023
The hybrid implicit–explicit finite-difference time-domain (HIE-FDTD) method is a weakly conditionally stable finite-difference time-domain (FDTD) method that has attracted much attention in recent years. However due to the dispersion media such as water,
Juan Chen, Chunhui Mou
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Autoformer‐Driven Convolutional Perfectly Matched Layer for 2D HIE‐FDTD Method

IET Microwaves, Antennas & Propagation
An innovative deep‐learning driven convolutional perfectly matched layer (CPML) integrated into the hybrid implicit‐explicit finite‐difference time‐domain (HIE‐FDTD) method is proposed to improve the efficiency of open‐region electromagnetic simulations.
Yexin Li, Xinjun Hu, Jing Wang, Kuiwen Xu, Ning Xu   +4 more
doaj   +1 more source

Simplified Tunnel–Soil Model Based on Thin-Layer Method–Volume Method–Perfectly Matched Layer Method

Applied Sciences
In order to analyze the ground vibration responses induced by the dynamic loads in a tunnel, this paper proposes a new simplified tunnel–soil model.
Yu Wang, Mengfan Zhou, Yanmei Cao, Xiaoxi Wang, Zhe Li, Meng Ma   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An Improved Uniaxial Perfectly Matched Layer Based on Finite Element Method for Hyperbolic Media

IEEE Open Journal of Antennas and Propagation
Recently, hyperbolic media (HM) has attracted considerable interest due to their open isofrequency contour (IFC) and high-k modes, while their numerical computational methods in infinite space are challenging.
Na Liu, Yansheng Gong, Rui Xu, Huanyang Chen, Guoxiong Cai   +4 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

A Normal Mode Model Based on the Spectral Element Method for Simulating Horizontally Layered Acoustic Waveguides

Journal of Marine Science and Engineering
Acoustic waves are essential tools for guiding underwater activities. For many years, numerical modeling of ocean acoustic propagation has been a major research focus in underwater acoustics.
Yinuo Zhang, Houwang Tu, Yongxian Wang, Guojun Xu, Dongbao Gao   +4 more
doaj   +1 more source