Results 11 to 20 of about 2,827 (131)

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Ecotoxicology and Environmental Safety, 2023
Perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) are ubiquitous in various environmental and human samples.
Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu   +11 more
doaj   +1 more source

Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish

Environment International, 2022
Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and humans. Novel PFOS alternatives have been widely used following restrictions on PFOS, but little is known about their potential toxicity.
Qiyu Wang, Jing Huang, Shuai Liu, Caiyun Wang, Yuanxiang Jin, Hong Lai, Wenqing Tu   +6 more
doaj   +1 more source

Comparative stress response assessment of PFOS and its alternatives, F-53B and OBS, in wheat: An insight of toxic mechanisms and relative magnitudes

Ecotoxicology and Environmental Safety, 2023
Emerging alternatives to perfluorooctane sulfonate (PFOS), including 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and p-perfluorous nonenoxybenzene sulfonate (OBS), have been widely detected in the real environment as PFOS restriction. However,
Xiaoying Li, Zhan Wang, Yanhui Ge, Hongwen Sun, Lianying Zhang   +4 more
doaj   +1 more source

Perfluorooctane sulfonate in water and sediment from the Yangtze Estuary and coastal waters: Occurrence, partitioning and diffusion behavior and risk assessment

Emerging Contaminants, 2023
As an emerging environmental contaminant, perfluorooctane sulfonate (PFOS) has attracted increasing attention. This study investigated the occurrence, partitioning and diffusion behavior, and risk assessment of PFOS in 19 water and sediment samples ...
Jing Chen, Hong Huang, Ruijing Li, Jinchen Yu, Zhiming Hu, Xu Zhao, Yang Li, Wenqian Wang   +7 more
doaj   +1 more source

Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach

Environment International, 2020
Background: Environmental exposure to perfluorooctane sulfonate (PFOS) is associated with various adverse outcomes in humans. However, risk assessment for PFOS with the traditional risk estimation method is faced with multiple challenges because there ...
Wei-Chun Chou, Zhoumeng Lin
doaj   +1 more source

Estimation of PFOS emission from domestic sources in the eastern coastal region of China

Environment International, 2013
Perfluorooctane sulfonate (PFOS) and related chemicals (collectively “PFOS equivalents”) have been released to the environment through widespread consumer use and disposal of PFOS-containing products like carpet, leather, textiles, paper, food containers,
Shuangwei Xie, Yonglong Lu, Tieyu Wang, Shijie Liu, Kevin Jones, Andy Sweetman   +5 more
doaj   +1 more source

A machine learning approach to elucidating PFOS-induced alterations of repressive epigenetic marks in kidney cancer cells with single-cell imaging

Environmental Advances, 2023
Perfluorooctane sulfonate (PFOS) is a synthetic chemical and an environmental pollutant widely recognized for its industrial use, given its thermal and chemical stability.
Wenjie Liu, Xiaohui Zhang, Yi Wen, Mark A. Anastasio, Joseph Irudayaraj   +4 more
doaj   +1 more source

Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification

Environment International, 2019
A challenge in the risk assessment of perfluorooctane sulfonate (PFOS) is the large interspecies differences in its toxicokinetics that results in substantial uncertainty in the dosimetry and toxicity extrapolation from animals to humans. To address this
Wei-Chun Chou, Zhoumeng Lin
doaj   +1 more source

Are perfluorooctane sulfonate alternatives safer? New insights from a birth cohort study

Environment International, 2020
Background: Experimental studies show that chlorinated polyfluorinated ether sulfonic acids (Cl-PFESA 6:2 and 8:2), one of perfluoroalkyl substances (PFAS) used as perfluorooctane sulfonate (PFOS) alternatives, are reproductive toxicants in vivo and in ...
Chu Chu, Yang Zhou, Qing-Qing Li, Michael S. Bloom, Shao Lin, Yun-Jiang Yu, Da Chen, Hong-Yao Yu, Li-Wen Hu, Bo-Yi Yang, Xiao-Wen Zeng, Guang-Hui Dong   +11 more
doaj   +1 more source

Protective effect of paeoniflorin on PFOS-induced oxidative liver damage in mouse models [PDF]

Xin yixue, 2022
Objective To investigate the effect of perfluorooctane sulfonate （PFOS） in mice. Methods The mouse models of oxidative liver injury were established by gavage of potassium perfluorooctane at a dose of 10 mg/kg for consecutive 18 d.
Li Zan, Yan Dingyi, Jiang Ran, Lu Kang, Cao Yali, Chen Lanhua, Luo Min, Huang Chunxia
doaj   +1 more source