Results 121 to 130 of about 5,607 (280)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
ProstorThe monograph provides a precise section through the work of the practice founded in Lagos in 1955 and active throughout the decades. Within the context of pre- and post-independence Nigeria, its relevance is examined in terms of social role and climate ...
Mojca Smode Cvitanović
doaj
Digital twins as run-time predictive models for the resilience of cyber-physical systems: a conceptual framework. [PDF]
Philos Trans A Math Phys Eng Sci, 2021 Flammini F.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Integrated avionics reliability [PDF]
The integrated avionics reliability task is an effort to build credible reliability and/or performability models for multisensor integrated navigation and flight control.
Alikiotis, Dimitri
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Bottlenecks in Two-Hop Ad Hoc Networks - Dividing Radio Capacity in a Smart Way [PDF]
, 2006 In two-hop ad hoc networks the available radio capacity tends to be equally shard among the contending stations, which may lead to bottleneck situations in case of unbalanced traffic routing.
Cloth, L., Haverkort, B.R., Remke, A.
core +1 more source
Empirical Study of Large-Scale HLA Simulation of Parallel Region-Matching Knowledge Recognition Algorithm Based on Region Matching. [PDF]
Comput Intell Neurosci, 2022 Zhu G, Wang H.
europepmc +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source