Results 101 to 110 of about 35,129,579 (242)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Performance-Based approach in seismic design of embedded retaining walls [PDF]
, 2008 The increasing use of the underground spaces and the last seismic events in the urban areas have driven many researchers of different countries to deepen the knowledge on the dynamic behaviour of the structure embedded in the subsoil.
Visone, Ciro
core +1 more source
BuildingsWith accelerating urbanization and climate change, outdoor thermal comfort (OTC) in high-intensity urban blocks presents a critical challenge. While existing studies have established the general correlation between morphology and microclimate, most ...
Junhan Zhang +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2002 [Abstract]: A performance-based optimization (PBO) method for optimal topology design of linear elastic continuum structures with mean compliance constraints is presented in this paper.
Steven, Grant P., Liang, Qing Quan
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Rivista Italiana di Acustica, 2020 La ricerca ha investigato quanto il progetto architettonico di una facciata possa contribuire al miglioramento del confort acustico in un canyon urbano in presenza di rumore da chiacchiericcio in strada.
Elena Badino +3 more
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Combining Axiomatic Design and Case-Based Reasoning in a Design Methodology of Mechatronics Products [PDF]
, 2009 Organised by: Cranfield UniversityCurrent market environments are volatile and unpredictable. The ability for design products to meet customer’s requirements has become critical to success.
Janthong, N., Brissaud, D., Butdee, S.
core +1 more source