Results 81 to 90 of about 68,438 (168)

Structural Response of a Steel-Frame Building to Traveling Fire

Fire
This article investigates the response of an unprotected three-storey steel moment-resisting frame subjected to a suite of horizontally traveling fire scenarios.
Amit Chandra, Anjan K. Bhowmick, Ashutosh Bagchi   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An overview of performance-based seismic design methodology for bridges

Tạp chí Khoa học và Công nghệ
The Performance-Based Seismic Design (PBSD) is an advanced approach to designing earthquake-resistant structures, ensuring that a building meets specific performance objectives under seismic impacts.
Nguyen Hoang Vinh, Doan Cong Chanh, Phan Hoang Nam, Hoang Phuong Hoa, Gianluca Quinci   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Development of a Performance-Based Design Technique for an Axial-Flow Fan Unit Using Airfoil Cascades Based on the Blade Strip Theory

Applied Sciences
Axial-flow fans are widely used as cooling fans in the outdoor units of split-type air conditioners. The design of an axial-flow fan blade involves stacking several airfoils that can be differently designed for each spanwise section. However, the complex
Seo-Yoon Ryu, Cheolung Cheong, Jong Wook Kim, Byung Il Park   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Parallel typological optimization in architectural design: a ResNet-enhanced island-based evolutionary algorithm

Journal of Asian Architecture and Building Engineering
Evolutionary optimization has become a widely adopted approach in performance-based building design. It enables the discovery of high-fitness solutions through iterative search processes.
Zexu Deng, Likai Wang, Guohua Ji, Qianhui Long   +3 more
doaj   +1 more source

Machine Learning Synthesis of Fire-Following-Earthquake Fragility Surfaces for Steel Moment-Resisting Frames

Infrastructures
This paper presents a probabilistic methodology for generating fragility surfaces for low- to mid-rise steel moment-resisting frames (MRFs) under fire-following-earthquake (FFE).
Mojtaba Harati, John W. van de Lindt
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source