Results 171 to 180 of about 89,449 (251)

Qualitative Analysis of Substance Uses Among Wollega University Undergraduate Students, Wollega, Western Ethiopia, 2025: An Exploratory Qualitative Study. [PDF]

Health Sci Rep
Keno FB, Abdissa E, Ewunetu A, Biru D, Gurmu G, Mekonnen L, Abebe D, Ephrem K, Tafasa SM, Fikadu W, Tamasgen W, Fetensa G.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A Bibliometric Analysis of Global Research Hotspots and Progress on Microbial Extracellular Polymeric Substances in Bioremediation. [PDF]

Microorganisms
Yan S, Xue S, Lv X, Li J, Ma N, Wang M, Quan Y.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. [PDF]

Front Endocrinol (Lausanne)
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

An integrative multi-omics investigation into the influence of forage type on the volatile flavor profile of Ujumqin sheep mutton. [PDF]

Front Vet Sci
Sachula W, Huimin L, Yaxing Z, Ding Y, Shangxiong Z, Shengli L, Haizhou S, Chunhua Z.   +7 more
europepmc   +1 more source

A national study of substance use behaviors among NCAA male athletes who use banned performance enhancing substances. [PDF]

Drug Alcohol Depend, 2013
Buckman JF, Farris SG, Yusko DA.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The influence of self-esteem and self-efficacy on doping susceptibility and intention in amateur athletes and exercisers. [PDF]

Front Sports Act Living
Zazueta-Beltrán DK, Morales-Beltrán RA, Cruz-Morales KN, Muñoz-Helú H, Ríos-Mena JA, Reynoso-Sánchez LF.   +5 more
europepmc   +1 more source