Results 251 to 260 of about 4,630,614 (319)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Kinetostatic Modeling and Performance Analysis of a Symmetric Redundant-Actuated 4-PSS Compliant Parallel Micro-Motion Mechanism. [PDF]

Micromachines (Basel)
Ren J, Lu Y.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Performance analysis of a three-dimensional micromixer with baffles using a flexible physics-informed neural network. [PDF]

Sci Rep
Hassanzadeh M, Ghaderi E, Bijarchi MA.
europepmc   +1 more source

Application-oriented classification and performance analysis of precision linear feed mechanisms for machine tools. [PDF]

Sci Prog
Zhou J, Yu H, He M, Zhang Y, Luan X, Liu Y.   +5 more
europepmc   +1 more source

Design and performance analysis of bionic trabecular bone scaffold structure based on Voronoi. [PDF]

J Biol Eng
Liu L, Wang X, Wang S, Liu J, Yang J, Zhou C.   +5 more
europepmc   +1 more source

Design and cutting performance analysis of cylindrical gear skiving tool with uniform working rake angle. [PDF]

Sci Rep
Ji J, Wang P, Xue R, Wang T, Xing K, Li J.   +5 more
europepmc   +1 more source

Fire performance analysis for buildings

, 2017
Meacham, Brian J., Fitzgerald, Robert W.
core  

From scale development to strategic action: internal service quality and importance-performance analysis findings in Taiwan's long-term care. [PDF]

BMC Health Serv Res
Chang CC, Huang SH.
europepmc   +1 more source