Results 261 to 270 of about 68,692,306 (348)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Theoretical modeling and performance analysis of a direct-indirect dual-layer flat-panel detector for contrast-enhanced breast imaging. [PDF]

Med Phys
Wu X, Howansky A, Huang H, Duan X, Arnab SM, Gamache A, Warmoes P, Laperrière L, Zhao W.   +8 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Modeling and Performance Analysis of a Liquid Desiccant Cooling and Dehumidification System Using ITSO-TCN-BiGRU-SA. [PDF]

Sensors (Basel)
Ou X, Wang X, Wang Z.
europepmc   +1 more source

Comparative performance analysis of public-private partnership hospitals in Türkiye. [PDF]

BMC Health Serv Res
Küçük A, Özsoy VS.
europepmc   +1 more source

Comparative evaluation of deep learning models for plant disease classification with edge-aware performance analysis. [PDF]

PLoS One
Hasani Z, Fondaj J, Bytyqi D, Misini S.
europepmc   +1 more source

Modeling and Performance Analysis of a Hybrid Forward Osmosis-Membrane Distillation System for Seawater Desalination. [PDF]

Membranes (Basel)
Triki Z, Fergani Z, Tahraoui H, Moula N, Zhang J, Amrane A, Fadhilah F, Assadi AA.   +7 more
europepmc   +1 more source

Variant calling in genomics: A comparative performance analysis and decision guide. [PDF]

PLoS One
Pinto V, Sousa L, Silva C.
europepmc   +1 more source

Attention-Based Multimodal Framework for Athlete-Performance Analysis and Rehabilitation Monitoring Using Vision and Wearable Sensors. [PDF]

Bioengineering (Basel)
Alonazi M, Abro IA, Abdelhaq M, Alsaqour R, Jalal A, Liu H.   +5 more
europepmc   +1 more source