Results 161 to 170 of about 617,802 (334)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Is the Price Right? Assessing Estimates of Cadastral Values for Bogotá, Colombia [PDF]
Hedonic house price models are increasingly applied in the process of mass appraisal, in which econometric specifications are used to obtain automated valuation of properties for taxation purposes.
Luc Anselin, Nancy Lozano-Gracia
core
Effectiveness of Performance Appraisal System in Large and Medium Size Manufacturing Organisations
, 2014 Iosr Journals +1 more
openalex +1 more source
Employees' Perception of the Fairness of Performance Appraisal Process in INGOs in Yemen
, 2022 Prof. Dr. Ahmed Al-Baidhani أ. د. احمد البيضاني +1 more
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Pro-poor intervention strategies in irrigated agriculture in Asia: poverty in irrigated agriculture: issues and options: Indonesia [PDF]
Irrigated farming / Poverty / Institutional development / Irrigation management / Colonialism / Policy / Privatization / Hydrology / Climate / Cropping systems / Soils / Participatory rural appraisal / Performance indexes / Crop production / Costs ...
Arif, Sigit +9 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source