Results 181 to 190 of about 71,517 (249)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Zero-shot interpretable biomedical literature appraisal with generative large language models. [PDF]

JAMIA Open
Zhou F, Afzal M, Saha A, Parrish R, Haynes RB, Iorio A, Lokker C.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Relationships among athletes' challenge and threat perceptions, mindfulness, and anxiety. [PDF]

Front Psychol
Karademir MB, Çalışır M, Yıldız AB, Tolukan E, Zararsız Ş, Aydın B, Gülşen DBA.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The mediating role of personality traits in the relationship between challenge threat appraisal and pro-antisocial behaviors. [PDF]

Front Psychol
Sitti S, Dincel S, Solmaz S, Emre Yarayan Y, Şimşek B.   +4 more
europepmc   +1 more source

Enhancing products performance evaluation through hybrid DistilRoBERTa and BiGRU models. [PDF]

PLoS One
Ullah S, Khan A, Ullah A, Khan MN, Chohan RT, Aadil F, Khan KU.   +6 more
europepmc   +1 more source

Emotional intelligence mediates the relationship between sport type and social anxiety in adolescents. [PDF]

Front Sports Act Living
Fernandes HM, Costa H, Esteves PT, Fonseca T, Honório S, Machado-Rodrigues AM.   +5 more
europepmc   +1 more source

Building Research Competence Across a Nursing Program: A Descriptive Documentary Study. [PDF]

Nurs Rep
Nunes L, Cerqueira AF, Poeira A.
europepmc   +1 more source

Integrative psychological interventions for stress regulation in sport: a mini-review. [PDF]

Front Sports Act Living
Alkasasbeh WJ, Grivas GV, Amawi AT.
europepmc   +1 more source