Results 181 to 190 of about 71,752 (251)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Applying Automated Artificial Intelligence Models on Lateral Cephalometric Parameters to Accurately Classify Arab Orthodontic Patient Patterns. [PDF]

Clin Exp Dent Res
Midlej K, Proff P, Watted N, Iraqi FA.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evaluating the diagnostic accuracy of neural network models in detecting oral potentially malignant disorders and oral cancer using mobile photographs: An umbrella review. [PDF]

Dent Res J (Isfahan)
Kumar PDM, Selvam R, Sivakumar S, Lavanya C, Kannan R.   +4 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Zero-shot interpretable biomedical literature appraisal with generative large language models. [PDF]

JAMIA Open
Zhou F, Afzal M, Saha A, Parrish R, Haynes RB, Iorio A, Lokker C.   +6 more
europepmc   +1 more source

Relationships among athletes' challenge and threat perceptions, mindfulness, and anxiety. [PDF]

Front Psychol
Karademir MB, Çalışır M, Yıldız AB, Tolukan E, Zararsız Ş, Aydın B, Gülşen DBA.   +6 more
europepmc   +1 more source

The mediating role of personality traits in the relationship between challenge threat appraisal and pro-antisocial behaviors. [PDF]

Front Psychol
Sitti S, Dincel S, Solmaz S, Emre Yarayan Y, Şimşek B.   +4 more
europepmc   +1 more source

Enhancing products performance evaluation through hybrid DistilRoBERTa and BiGRU models. [PDF]

PLoS One
Ullah S, Khan A, Ullah A, Khan MN, Chohan RT, Aadil F, Khan KU.   +6 more
europepmc   +1 more source