Results 141 to 150 of about 2,247,745 (314)
Risk and Performance Based Fire Safety Design of Steel and Composite Structures [PDF]
, 2009 For the development of performance based design on a proper scientific basis the use of the concept of risk is inevitable. However, the application of this concept to actual structural design is not simple because of the large ranges of probability ...
Lange, David
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
An investigation of constraint-based risk management for collaborative design
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In the context of internationally challenging economic, design has been regarded as a key factor in assisting design and manufacturing companies to survive.
Ruan, Jian
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
RESSLABKeynote Lecture, as part of the International Workshop on Performance-Based Seismic Design of Structures in Tongji ...
Lignos, Dimitrios
core
Design activity modelling : a performance viewpoint
, 2001 Design activity modelling has received significant attention in research over the last 30 years with a focus on both descriptive and prescriptive models.
Duffy, A.H.B., O'Donnell, F.J.
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source