Results 131 to 140 of about 2,247,745 (314)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Design Performance Measurement in the Construction Sector: A Pilot Study [PDF]

This paper examines the role and deployment of design performance measurements (DPMs) in the construction industry, focusing on the consulting engineering sector, the design 'heart' of construction. Compared with manufacturing, there has been very little
David M Gann, Mike Hobday, Ammon J Salter, Richard Torbett   +3 more
core  

An aerospace component cost modelling study for value driven design [PDF]

, 2009
Demand is increasing in aero-engine products for better efficiency and environmental performance whilst keeping the cost low. Unlike performance, the physics behind cost is least understood.
Cheung, J. M. W., Wiseall, S.S., Scanlan, J. P., Wiseall, S. S., Cheung, J.M.W., Scanlan, J.P.   +5 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Integrated Design Approach To Performance Based Design

, 2016
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2016Thesis (M.Sc.) -- İstanbul Technical University, Instıtute of Science and Technology, 2016Son yılardaki hızlı teknolojik gelişmeler hemen hemen bütün mesleki pratiklerin ...
Şahin Karagöz, Benan
core  

Dynamic sensitivity analysis for performance-based building design and operation [PDF]

, 2013
This paper presents dynamic sensitivity analysis as a novel design analysis tool for dealing with timevarying performance aspects in the built environment.
Loonen, R.C.G.M., Hensen, J.L.M., Loonen, R.C.G.M.; id_orcid, Loonen, RCGM Roel, Hensen, JLM Jan   +4 more
core  

Optimization of a Design Process and Passive Parameters for Residential Nearly Zero Energy Building Envelopes Based on Energy Consumption Targets

Buildings
The calculation of energy consumption in building plans is usually carried out after design completion, resulting in high time costs and hindering their application in the early design stage.
Jiaqi Xu, Tao Fang, Yanzheng Wang, Zhao Wang, Xitao Han   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Machine Learning Assessment of Fire Resistance in Seismically Designed Reinforced Concrete Structures

Fire
This research investigates the effect of seismic loading on FRRs of RC structures using different machine learning (ML) algorithms. First, 20 portal RC frames with varying span numbers and stories are designed for seismic loads.
Mohammadreza Amiraslankhan, Behrouz Behnam, Ehsan Nazerfard, Maedeh Haghbin Yousefi   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source